Multifunctional Pharmaceutical Nanocarriers

ISBN-13: 9780387765518 / Angielski / Twarda / 2008 / 474 str.

Vladimir Torchilin

Opis

The use of various pharmaceutical carriers to enhance the in vivo efficiency of many drugs and drug administration protocols has been well established during the last decade in both pharmaceutical research and clinical setting. Surface modification of pharmaceutical nanocarriers, such as liposome, micelles, na- capsules, polymeric nanoparticles, solid lipid particles, and niosomes, is normally used to control their biological properties in a desirable fashion and to simulta- ously make them perform various therapeutically or diagnostically important functions. The most important results of such modification include an increased stability and half-life of drug carriers in the circulation, required biodistribution, passive or active targeting into the required pathological zone, responsiveness to local physiological stimuli, and ability to serve as contrast agents for various imaging modalities (gamma-scintigraphy, magnetic resonance imaging, computed tomography, ultra-sonography). Frequent surface modifiers (used separately or simultaneously) include soluble synthetic polymers (to achieve carrier longevity); specific ligands, such as antibodies, peptides, folate, transferrin, and sugar moieties (to achieve targeting effect); pH- or temperature-sensitive lipids or polymers (to impart stimuli sensitivity); chelating compounds, such as EDTA, DTPA, and deferoxamine (to add a heavy metal-based diagnostic/contrast moiety onto a drug carrier). Certainly, new or modified pharmaceutical carriers (nanocarriers) as well as their use for the delivery of various drugs and genes are still described in many publications.

Spis treści

Multifunctional Pharmaceutical Nanocarriers: Development of the Concept.- Multifunctional Polymeric Nanosystems for Tumor-Targeted Delivery.- Nanogels as Pharmaceutical Carriers.- Multifunctional Water-Soluble Polymers for Drug Delivery.- “Smart” pH-Responsive Carriers for Intracellular Delivery of Biomolecular Drugs.- Stimuli-Sensitive Nanosystems: For Drug and Gene Delivery.- Functionalized Dendrimers as Nanoscale Drug Carriers.- Biodegradable Multitargeting Nanoconjugates for Drug Delivery.- Pharmaceutical Micelles: Combining Longevity, Stability, and Stimuli Sensitivity.- Multifunctional Nanotherapeutics for Cancer.- Charge Modification of Pharmaceutical Nanocarriers: Biological Implications.- Funtionalization of Pharmaceutical Nanocarriers for Mitochondria-Targeted Drug and DNA Delivery.- Multifunctional Magnetic Nanosystems for Tumor Imaging, Targeted Delivery, and Thermal Medicine.- Nanosystems for Multimodality In vivo Imaging.- Long-Circulating Liposomes with Attached Diagnostic Moieties: Application for Gamma and MR Imaging.

Blurb

Various pharmaceutical nanocarriers, such as nanospheres,nanocapsules, liposomes, micelles, cell ghosts, lipoproteins and some others are widely used for experimental (and already clinical) delivery of therapeutic and diagnostic agents. The use of nanoparticulate pharmaceutical carriers to enhance the in vivo efficiency of many drugs well established itself over the past decade both in pharmaceutical research and clinical setting. Looking into the future of the field of drug delivery, we have to think about the development of the next generation of pharmaceutical nanocarriers combining the whole variety of properties and allowing for the simultaneous performance of multiple functions. Surface modification of pharmaceutical carriers is often used to control their properties in a desirable fashion and make them to simultaneously perform several different functions. This book is all about these "futuristic" multifunctional medicines.

Key features:

-all chapters written by international leaders in the field

-offers the most recent innovations and discoveries related to nanopharmaceuticals

-detailed illustrations

-latest volume in the Fundamental Biomedical Technologies series

About the Editor:

Vladimir P. Torchilin, Ph.D., D.Sc. is a Distinguished Professor and Chair of the Department of Pharmaceutical Sciences and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Mass.