1. Introduction Yeliz Karaca and Dumitru Baleanu 2. Theory of Complexity, Origin and Complex Systems Yeliz Karaca 3. Multi-chaos, Fractal and Multi-fractional AI in Different Complex Systems Yeliz Karaca 4. High Performance Computing and Computational Intelligence Applications with Multi-Chaos Perspective Osvaldo Gervasi, Damiano Perri, Marco Simonetti, and Sergio Tasso 5. Human Hypercomplexity: Error and Unpredictability in Complex Multi-Chaotic Social Systems Piero Dominici Sr. 6. Multifractal Complexity Analysis-based Dynamic Media Text Categorization Models by Natural Language Processing with BERT Yeliz Karaca, Yu-Dong Zhang, Ahu Dereli Dursun, and Shui-Hua Wang 7. Mittag-Leffler Functions with Heavy-tailed Distributions' Algorithm based on Different Biology Datasets to be Fit for Optimum Mathematical Models' Strategies Dumitru Baleanu and Yeliz Karaca 8. Artificial Neural Network Modeling of Systems Biology Datasets Fit Based on Mittag-Leffler Functions with Heavy-tailed Distributions for Diagnostic and Predictive Precision Medicine Yeliz Karaca and Dumitru Baleanu 9. Computational Fractional-Order Calculus and Classical Calculus AI for Comparative Differentiability Prediction Analyses of Complex-systems-grounded Paradigm Yeliz Karaca and Dumitru Baleanu 10. Pattern Formation Induced by Fractional-order Diffusive Model of COVID-19 Yeliz Karaca and Naveed Iqbal 11. Prony's series in time and frequency domains and relevant fractional models Jordan Hristov 12. A chain of kinetic equations of Bogoliubov-Born-Green-Kirkwood-Yvon and its application to non-equilibrium complex systems Mukhayo Rasulova V, Tohir Vohidovich Akramov, Nicolai (Jr) Bogoliubov, and Umarbek Avazov 13. Hearing Loss Detection in Complex Setting by Stationary Wavelet Rényi Entropy and Three-Segment Biogeography-Based Optimization Yabei Li, Junding Sun, and Chong Yao 14. Shannon Entropy-based Complexity Quantification of Nonlinear Stochastic Process: Diagnostic and Predictive Spatio-temporal Uncertainty of Multiple Sclerosis Subgroups Yeliz Karaca, and Majaz Moonis 15. Chest X-ray image detection for pneumonia via complex convolutional neural network and Biogeography-based optimization Junding Sun, Xiang Li, and Mengyao Zhai 16. Complex facial expression recognition via Densenet-121 Bin Li 17. Quantitative assessment of local warming based on urban dynamics using remote sensing techniques. Valentina Santarsiero, Lucia Saganeiti, Angela Pilogallo, Francesco Scorza, Beniamino Murgante, Valentina Santarsiero, and Gabriele Nolè 18. Managing Information Security risk and Internet of Things (IoT) Impact on Challenges of Medicinal Problems with Complex Settings: A Complete Systematic Approach N. Thirupathi Rao, Debnath Bhattacharyya, and Eali Stephen Neal Joshua 19. An Extensive Discussion on Utilization of Data Security and Big Data Models for Resolving Healthcare Problems N. Thirupathi Rao, Debnath Bhattacharyya, and Eali Stephen Neal Joshua