Mouse as a Model Organism: From Animals to Cells

ISBN-13: 9789400707498 / Angielski / Twarda / 2011 / 165 str.

Cord Brakebusch; Taina Pihlajaniemi

Opis

This fascinating book offers an introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It highlights the possibilities, but also discusses the current problems in this field.

Recenzje

"The book gives a good introduction to the possible way of exploiting the mouse system to explore the molecular pathways underlying human diseases, especially cancer. The concept of 'mouse clinics' and the high throughput phenotyping of mouse mutants ... described in the books will be watched with bated breath by all investigators of biomedical research, as these are the signposts of things to come in future." (N. V. Giridharan, Indian Journal of Medical Research, Vol. 136, October, 2012)

Spis treści

Preface; 1 Genomic insulators in transgenic animals, Lluís Montoliu et al; 2 The GERMAN MOUSE CLINIC – Running an open access platform, Martin Hrabé de Angelis et al.; 3 Nature & Nurture: impacts on mouse phenotypes & translational research, Cory Brayton; 4 X The informatics of high-throughput mouse phenotyping: EUMODIC and beyond, John M Hancock and Hilary Gates; 5 Experimental tumour models in mice, Ritva Heljasvaara and Taina Pihlajaniemi; 6 Exploration of MMP function in mouse models of angiogenesis, Agnès NOEL et al.; 7 Tumor- stroma interactions: focus on fibroblasts, Donald Gullberg* and Rolf K. Reed; 8 Experimental procedures to assay invasion-associated activities of primary cultured fibroblasts, Olivier De Wever et al.; 9 Systemic Instigation: A Mouse Model to Study Breast Cancer as a Systemic Disease, Sandra S. McAllister; Index