Monophasic Action Potentials: Basics and Clinical Application

ISBN-13: 9783642645853 / Angielski / Miękka / 2011 / 241 str.

Michael R. Franz; Claus Schmitt; Bernhard Zrenner

Opis

Over the last two decades monophasic action potential (MAP) recording has matured into a technique that provides a link between basic and clinical electrophysiology. International experts present exciting data on MAP recording techniques, the mechanism and interpretation of MAPs, and novel aspects of repolarization-related arrhythmias.

Spis treści

I Historical Development and MAP Recording Technique.- Historical Development of the Monophasic Action Potential Recording Technique.- Monophasic Action Potential Recordings: What Are They, How Can They Be Recorded, What Is Their Use?.- Basic Biophysical Characteristics of Fractally Coated Electrodes.- Recording of Monophasic Action Potentials with Fractally Coated Electrodes — Experimental and Initial Clinical Results.- II Evaluation of Anti- and Proarrhythmic Effects.- Rate Dependence of Antiarrhythmic and Proarrhythmic Properties of Class I and Class III Antiarrhythmic Drugs.- Frequency-Dependent Effects of Class III Antiarrhythmic Agents as Assessed by MAP Recordings — Possible Advantages of IKs Blockade.- Endothelin-Induced Ventricular Arrhythmias.- III Mechanisms: Atrial and Ventricular Arrhythmias.- The Effects of Atrial Fibrillation on the Monophasic Action Potential of the Caprine Atrium.- Excitable Gap, Antiarrhythmic Actions, Electrical Remodeling: The Role Of MAP Recording in Atrial Fibrillation And Other Atrial Tachyarrhythmias.- Propagated Graded Responses and Dispersion of Repolarization as Two Different Mechanisms of Ventricular Vulnerability to Reentry.- Mechanisms of Induction and Termination of Ventricular Fibrillation.- IV Ischemia — Dispersion.- Some Effects of Ischaemia and Changes in Ventricular Loading On Repolarisation.- Electrophysiological Characteristics of the M Cell.- Dispersion of Ventricular Repolarization — Myocardial and Electrocardiographic Markers.