Monoclonal Antibodies: Physicochemical Analysis

ISBN-13: 9780128223185 / Angielski / Miękka / 2021

Harleen Kaur; Dietmar Reusch

Spis treści

1. Overview of Monoclonal Antibodies
2. Physicochemical Characterisation of Monoclonal Antibodies
3. Glycosylation Analysis
4. The Use and Application of LC-MS-MS Petide Mapping Methodology for Primary Structure Confirmation, Sequence Variant Analysis and Comprehensive Analysis of Post-Translational Modifications
5. Separation Techniques for Characterization and Quantification of Antibody Purity
6. Higher Order Structure and Free Thiol
7. Advanced Structural Elucidation of New Antibody Formats by Mass Spectrometry

O autorze

Harleen Kaur, PhD, is affiliated with Aurobindo Pharma Ltd., in the Biologics Division, based in Hyderabad, India. Dr Kaur is the lead editor of Monoclonal Antibodies: Physicochemical Analysis. Her research focuses on the analytical development and characterization of large molecules, particularly mAbs, and on bringing therapeutic products from early discovery to commercial launch. Previously she has worked for AstraZeneca both in the United States and India and has extensive experience in technology transfer and development of biologics in a highly regulated environment. She earned her undergraduate degree from Guru Gobind Singh Indraprastha University, Delhi, India, and PhD degree from the National University of Singapore, Singapore. She is the author of many peer-reviewed publications and book chapters in the area of antibody characterization and aptamers. Dietmar Reusch, PhD, is affiliated with Roche Diagnostics GmbH in Germany. His research focuses on the analytical development and characterization of large molecules, particularly mAbs, and on bringing therapeutic products from entry into human to commercial launch.