Monoclonal Antibodies

ISBN-13: 9780521425032 / Angielski / Miękka / 1995 / 500 str.

Mary A. Ritter; Heather M. Ladyman;Ritter

Opis

This book is among the first to combine technical and clinical aspects of the subject. It aims to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications of these antibodies. Many areas of clinical medicine benefit from this type of study including histopathology, oncology, transplantation, infectious diseases, rheumatology, haematology, and dermatology.

Recenzje

'The editors have done a fine job. There is little redundancy between chapters, the text is clear and all the contributions are well referenced.' British Toxicology Society Newsletter

Spis treści

1. Introduction; 2. Production of monoclonal antibodies; 3. Antigen–antibody interactions: how affinity and kinetics affect assay design and selection procedures; 4. The production and characterisation of synthetic peptide-derived antibodies; 5. Human monoclonal antibodies; 6. Bispecific monoclonal antibodies; 7. The production of antibodies using phage display libraries; 8. Genetic manipulation of monoclonal antibodies; 9. Monoclonal antibodies in diagnostic immunoassays; 10A. Monoclonal antibodies in diagnostic pathology; 10B. In vivo targeting of monoclonal antibodies for immunoscintigraphy and therapy of human malignancies; 11A. Monoclonal antibodies in infectious disease: diagnosis; 11B. Monoclonal antibodies in the prophyllaxis and therapy of infectious disease; 12A. Monoclonal antibodies in transplantation: immunohistology; 12B. Monoclonal antibodies in transplantation: experimental studies on in vivo immunosuppression; 12C. Monoclonal antibodies in transplantation: prophyllaxis of graft-versus-host disease after bone marrow transplantation; 12D. Monoclonal antibodies in transplantation: use as therapeutic agents in clinical organ transplantation; 13. Monoclonal antibodies and the skin; 14. Monoclonal antibodies in endocrinology; 15. Monoclonal antibodies in rheumatology; 16. Technical appendix.