Molecular Tools and Infectious Disease Epidemiology

ISBN-13: 9780123741332 / Angielski / Twarda / 2011 / 215 str.

Betsy Foxman

Opis

Molecular Tools and Infectious Disease Epidemiology examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology; discusses how using molecular tools in epidemiologic research affects program design and conduct; considers the ethical concerns that arise in molecular epidemiologic studies; and provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into his or her studies.

• Presents the key points of consideration when integrating molecular biology and epidemiology
• Discusses how using molecular tools in epidemiologic research affects program design and conduct
• Considers the ethical concerns that arise in molecular epidemiologic studies
• Provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field

Spis treści

1. Introduction and Historical Perspective2. How Molecular Tools Enhance Epidemiologic Studies3. Applications of Molecular Tools to Infectious Disease Epidemiology4. A Primer of Epidemiologic Study Designs5. A Primer of Molecular Biology 6. Molecular Tools7. Omics Analyses in Molecular Epidemiologic Studies 8. Determining the Reliability and Validity and Interpretation of a Measure in the Study Populations9. Designing and Implementing a Molecular Epidemiologic Study10. Study Conduct11. Think About Data Analysis When Planning a Study12. Human and Animal Subject Protection, Biorepositories, Biosafety Considerations, and Professional Ethics13 Future Directions

O autorze

Dr. Betsy Foxman is the Hunein F. and Hilda Maassab Professor of Epidemiology, Director of the Center for Molecular and Clinical Epidemiology of Infectious Diseases (MAC-EPID), Director of the Integrated Training in Microbial Systems (ITiMS) program, and Director of the Certificate Program in Healthcare Associated Infection Prevention and Control (CHIP) at the University of Michigan. Foxman received her Bachelor of Science in Conservation of Natural Resources from the University of California, Berkeley, and MSPH and PhD in Epidemiology from the UCLA School of Public Health. Foxman studies the transmission, pathogenesis, ecology, and evolution of infectious agents with an emphasis on transmission. Current research projects include studies of the interactions between viral infections and microbiota, vaginal microbiota and pre-term birth, the oral microbiota and dental health, and epidemiology of antibiotic resistant bacteria.