Molecular Targets in Protein Misfolding and Neurodegenerative Disease

ISBN-13: 9780128001868 / Angielski / Twarda / 2014 / 314 str.

Pierfausto Seneci

Opis

Aimed at "drug discoverers" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

• Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
• Provides a "drug discovery" application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
• Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
• Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
• Contains a more thorough description of the therapeutic relevance of 10 specific molecular targets

Recenzje

"...an excellent biology-oriented discussion of the role of protein misfolding in neurodegenerative diseases...along with the forthcoming companion book, will provide neuroscientists with a strong foundation in this very important topic. Score: 88 - 3 Stars" --Doody's

Spis treści

1. Protein misfolding, neurodegeneration and Tau: The main players, or the usual suspects?2. Targeting the protein quality control (PQC) machinery: The neuronal Salvation Army3. Proteasomal degradation of soluble, misfolded proteins: Throwing out the bath water, but where's the baby?4. Unselective disposal of cellular aggregates: Engulf, devour and digest to recycle5. Selective disposal of insoluble protein aggregates: Pick, transport and remove to cure6. Assembly and disassembly of protein aggregates: Unraveling the maze

O autorze

Dr. Pierfausto Seneci is Associate Professor in the Department of Organic and Industrial Chemistry at the University of Milan. He is currently affiliated with the University of Milan Centre for Interdisciplinary Biomolecular Studies and Industrial Applications (CISI) Centre of Excellence, and is responsible for the Combinatorial Chemistry/High Throughput MedChem Laboratory. He has over 20 years of medicinal chemistry experience working in industry, and held business development positions with GSK, Sanofi, and start-up pharmaceutical companies including Sirenade and NiKem working in drug discovery, neurodegeneration, oncology, and antibacterials. He is author of approximately 80 papers on the topic and several book chapters, including the book "Solid-Phase Synthesis and Combinatorial Technologies” with Wiley-Interscience in 2000.