Molecular Signaling in Spermatogenesis and Male Infertility

ISBN-13: 9780367199302 / Angielski / Twarda / 2019 / 182 str.

Rajender Singh

Opis

"Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book inludes chapters on most of the signaling pathways known to contribute to spermatogenesis"--

Spis treści

Primordial germ cells: Origin, migration and testicular development. DNA methylation, imprinting and gene regulation in germ cells. Testicular stem cells, spermatogenesis and infertility. Testicular germ cell apoptosis and spermatogenesis. Hormonal regulation of spermatogenesis. GH–IGF1 axis in spermatogenesis and male fertility. Retinoic acid signaling in spermatogenesis and male (in)fertility. Testosterone signaling in spermatogenesis, male fertility and infertility. Wnt signaling in spermatogenesis and male infertility. MAPK signaling in spermatogenesis and male infertility. TGF-β signaling in testicular development, spermatogenesis, and infertility. Notch signaling in spermatogenesis and male (in)fertility. Hedgehog signaling in spermatogenesis and male fertility. mTOR signaling in spermatogenesis and male infertility. JAK-STAT pathway: Testicular development, spermatogenesis and fertility. PI3K signaling in spermatogenesis and male infertility. Spermatogenesis, heat stress and male infertility