Molecular Pathology of Neoplastic Gastrointestinal Diseases

ISBN-13: 9781489973535 / Angielski / Miękka / 2015 / 277 str.

John P Lynch;Antonia R Sepulveda

Opis

This book reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with up to date knowledge. It features practical applications, tables, and diagrams.

Spis treści

Section 1. Introduction    

 

1.    Mechanisms of Gastrointestinal Carcinogenesis         

By Frank I. Scott and John P. Lynch

 

Section 2. Epithelial Neoplastic Disease        

 

2.    Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers

By Davendra Sohal, Antonia R. Sepulveda, and Weijing Sun

 

3.    Molecular Pathology of Barrett's Metaplasia and Esophageal Adenocarcinoma

By Mamoun Younes

 

4.    Molecular Pathology of Squamous Carcinomas of the Esophagus 

By Rohinton S. Tarapore and Jonathan P. Katz

 

5.    Molecular Mechanisms and Pathology of Gastric Carcinogenesis: Sporadic Cancers    

By Shuko Harada and Antonia R. Sepulveda

 

6.    Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes

By Fatima Carniero, Carla Oliveira, and Raquel Seruca

 

7.    Cancer Predisposition Syndromes of the Gastrointestinal Tract       

By Ian S. Hagemann and Antonia R. Sepulveda

 

8.    Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Types

By Asif Rashid

 

9.    Cancers of the Rectum and Anal Canal

By Jenia Jenab-Wolcott and Bruce Giantonio

 

10. Molecular Pathology of Inflammatory Bowel Disease Associated Neoplasia         

By Takeshi Uehara, Deqin Ma, and Antonia R. Sepulveda

 

Section 3. Non-Epithelial Neoplastic  Tumors          

 

11. Molecular Biology and Pathology of Gastrointestinal Stromal Tumors         

By Paul J Zhang

 

12. Neuroendocrine Tumors   

By Joseph R Pisegna

 

Section 4. Metastatic Disease and Tumor Markers  

 

13. Molecular Mechanisms of Tumor Metastases   

By Andrew Rhim, Davendra Sohal, and Hiroshi Nakagawa

 

14. Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis

By Loren Joseph

 

15. Serological Markers of Digestive Tract Cancers           

By Jorge L Sepulveda

 

By Andrew Rhim, Davendra Sohal, and Hiroshi Nakagawa

 

14. Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis

By Loren Joseph

 

15. Serological Markers of Digestive Tract Cancers           

By Jorge L Sepulveda

Blurb

Molecular Pathology of Neoplastic Gastrointestinal Diseases  reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on:

• the molecular basis of the individual disease
• molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies
• recommended guidelines for clinical application of molecular tests are included whenever available
• molecular testing for hereditary predisposition or disease risk
• animal models and cell culture models of disease