Molecular Pathology of Liver Diseases

ISBN-13: 9781441971067 / Angielski / Twarda / 2010 / 931 str.

Satdarshan P. S. Monga

Opis

Molecular Pathology of Liver Diseases is an important component of the Molecular Pathology Library Series by Springer. In this day and age, molecular mechanism of a disease is an integral part of the thought process of the practicing health care provider. Unlike basic scientists who are trained to understand the intricacies of molecular signaling and their interactions in health and disease, many in the clinical arena might feel a void in their knowledge of these complex mechanisms. Also, with increasing translational applications of the molecular biology, especially in the discipline of molecular pathology, it is of greater significance to generate resources capable of: (i) providing fundamental concepts of organ-based molecular pathology for the trainees; (ii) providing continued education to the trained (how about practicing pathologist) keeping them abreast of the timely modalities and shifting paradigms and; (iii) providing cross-discipline opportunities fostering molecular biology as a discipline. Molecular Pathology of Liver Diseases is an attempt to serve these functions in an ever-evolving field of Liver Pathobiology. Cellular and Molecular Pathology of the Liver is extensive, complex and ranges from the understanding the basic molecular mechanisms that dictate everything from liver homeostasis to liver disease. Molecular Pathology of the liver is complicated due to some of the important functions inherent and unique to the Liver, including its innate ability to regenerate and the multitude of functions it plays for the wellbeing of an organism. With all this in mind, Molecular Pathology of Liver Diseases is organized in different sections, which will coherently and cohesively present the molecular basis of hepatic physiology and pathology. The first two sections are key to understanding the liver anatomy and physiology at a cellular level and go on to define the molecular mechanics in various liver cell types. These sections also cover the existing paradigms in liver development, regeneration and growth. The next section is key to understanding the Molecular Pathology unique to liver diseases and associated phenotypes. The final sections are geared towards the existing knowledge of the molecular basis of many common and uncommon liver diseases in both neoplastic and non-neoplastic areas including pathologies associated with intra-hepatic and extra-hepatic biliary tree. Thus, this textbook is a one-stop reference for comprehending the molecular mechanisms of hepatic pathobiology. It is clearly unique in its format, readability and information and thus will be an asset to many in the field of Pathology and other disciplines.

Spis treści

Molecular Basis of Hepatic Physiology.- Gross and Cellular Anatomy of the Liver.- Liver Zonation.- Hepatocytes.- Biliary Epithelial Cells.- Stellate Cells.- Kupffer Cells.- Sinusoidal Endothelial Cells.- Carbohydrate Metabolic Functions of the Liver.- Protein Metabolic Functions of the Liver.- Fat Metabolic Functions of the Liver.- Detoxification Functions of the Liver.- Synthetic Functions of the Liver.- Bilirubin Metabolism.- Bile Acid Metabolism.- Liver Development.- Transcriptional Control of Hepatic Differentiation.- Liver Regeneration.- Liver Stem Cells.- Apoptosis and Necrosis.- Hepatic Fibrosis and Cirrhosis.- Ischemia-reperfusion Injury.- Fatty Liver.- Cholestasis.- Portal Hypertension.- Inflammation.- Oxidative Stress.- NAFLD.- ALD.- Viral Hepatitis.- Autoimmune Hepatitis.- Toxic Liver Injury.- Wilson's Disease.- Hemochromatosis.- Glycogen Storage Diseases.- al-Antitrypsin Deficiency.- Hepatic Artery Obstruction.- Portal Vein Obstruction.- Hepatic Vein Thrombosis.- Primary Biliary Cirrhosis.- Primary Sclerosing Cholangitis.- Benign Hepatic Tumors.- Benign Biliary Tumors.- Experimental Carcinogenesis.- Cancer Stem Cells.- Primary Hepatocellular Carcinoma.- Fibrolamellar Variant of HCC.- Metastatic Diseases to the Liver.- Cholangiocarcinoma.- Molecular Pathology of Extrahepatic Bile Ducts and Gall Bladder.- Developmental Disorders of the Extrahepatic Bile Duct.- Choledocholithiasis, Cholangitis, Gallstones.- and Cholecystitis.- Carcinoma of Extrahepatic Bile Duct.- Gall Bladder Neoplasms.- Index.

O autorze

Satdarshan (Paul) Singh Monga, M.D. is Director: the Division of Experimental Pathology and Associate Professor of Pathology and Medicine, University of Pittsburgh, Pittsburgh, PA

Blurb

Molecular Pathology of Liver Diseases integrates the traditional knowledge of physiological and pathological processes in the liver with a balanced emphasis on fundamental concepts; timely advances in cellular and molecular mechanisms; and applied pathology. The textbook is organized into several sections, each of which includes an array of chapters that progressively and cohesively elaborate on pertinent liver biology and pathology. The first three sections discuss the cellular composition of the liver along with their specialized functions, and further dissect the molecular basis of the cellular processes that are so unique to the liver. The next section examines the mechanisms that are commonly implicated in the cellular and molecular basis of several hepatic pathologies, followed eventually by a section each on a multitude of non-neoplastic and neoplastic diseases of the liver. Molecular Pathology of Liver Diseases is a comprehensive reference on liver pathobiology for basic, translational and clinical researchers and physicians The format of the volume will serve as a ready reference to relevant topics in the liver, thus providing a practical disease-based integrative resource on the molecular pathology of liver disease. Satdarshan (Paul) Singh Monga, MD is Director: Division of Experimental Pathology and Associate Professor of Pathology and Medicine, University of Pittsburgh, Pittsburgh, PA