Molecular Paradigms of Infectious Disease: A Bacterial Perspective

ISBN-13: 9781441940421 / Angielski / Miękka / 2010 / 646 str.

Cheryl A. Nickerson; Michael Schurr

Opis

Infectious diseases caused by bacterial pathogens are a leading cause of human illness and death worldwide. The study of bacterial pathogenesis has changed dramatically over the last decade, as a result of revolutionary changes in biotechnology and our understanding of molecular and cellular biological systems. This volume is structured to emphasize paradigms of infectious disease that have emerged over the last 10 years and provides a fundamental understanding of the complex cellular and molecular processes that are important for bacterial virulence and the infectious disease process. The book highlights key techniques and methodologies that have driven recent discoveries in bacterial pathogenesis, major structures and mechanisms in bacteria that are important for their pathogenesis, the regulation of these virulence determinants by global regulators, and bacterial biowarfare agents.

Spis treści

Genetic Analysis of Bacterial Pathogenesis.- Genetic Exchange in Bacteria and the Modular Structure of Mobile DNA Elements.- Genomics and the Use of Genomic Tools to Study Pathogenic Bacteria.- Pathogenicity Islands and Bacterial Virulence.- Capsules.- Bacterial Cell Walls.- Mechanisms of Bacterial Adhesion and Consequences of Attachment.- Bacterial Invasion into Non-Phagocytic Cells.- Bacterial Protein Secretion Mechanisms.- Toxins as Host Cell Modulators.- Quorum Sensing: Coordinating Group Behavior Through Intercellular Signals.- The Role of Sigma Factors in Regulating Bacterial Stress Responses and Pathogenesis.- Two-Component Regulatory Systems.- Oxidative Stress Systems in Bacteria: Four Model Organisms.- Bacterial Biowarfare Agents.

O autorze

Michael Schurr, Berater für strategisches Prozessmanagement im Gesundheitswesen. Mehr als 20 Jahre Erfahrung in der Beratung ambulanter Leistungserbringer in unterschiedlichen Beratungs- und Führungspositionen. 1995 Entwicklung eines ganzheitlich betriebswirtschaftlichen Prozesssteuerungsprogramms für Ärzte und Zahnärzte. Entwicklung und Geschäftsführer der DUXXESS - Gesellschaft für Medizinisches Erfolgsmanagement mbH.Dozent am Institut für Gesundheitsmanagement der Hochschule Deggendorf. Mitglied der European Pathway Association (EPA) und der Deutschen Medizinischen Standespresse.

Blurb

This comprehensive volume, written by leading authors in the field, provides a fundamental understanding of the complex cellular and molecular processes that are important for bacterial virulence and the infectious disease process. Written in a clear and engaging manner, the book highlights key techniques and methodologies that have driven recent discoveries in bacterial pathogenesis, major structures and mechanisms in bacteria that are important for the pathogenesis of these organisms, the regulation of these virulence determinants by global regulators, and bacterial biowarfare agents. Molecular Paradigms of Infectious Disease: A Bacterial Perspective is an ideal book for students, microbiologists, immunologists and scientists and researchers of bacterial pathogenesis.