Molecular Neurology

ISBN-13: 9780123695093 / Angielski / Twarda / 2007 / 584 str.

Stephen G. Waxman

Opis

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.

• Describes the newest molecular aspects of neurological disorders
• Provides an introduction to neurological disorders for basic scientists
• Updates clinicians and clinical researchers on the most recent developments

Spis treści

PREFACE - Stephen G. Waxman

Section I. Principles of Molecular Neurology.
Genetics as a Tool in Neurology.
Neurology and Genomic Medicine.
Mitochondrial Function and Dysfunction in the Nervous System.
Neuronal Channels and Receptors.
Protein Misfolding, Chaperone Networks, and the Heat Shock Response
in the Nervous System.
Metabolic Biopsy of the Brain.
Gene therapy approaches in neurology.
Programmed Cell Death and its Role in Neurological Disease.

Section II. Disorders of Development.
Developmental Neurology: A Molecular Perspective.
Metabolic Diseases of the Nervous System.
Genetic Disorders of Neuromuscular Development.

Section III. Stroke and Trauma.
Molecular Mechanisms of Ischemic Brain Disease.
Hemorrhagic Brain Disease.
The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury.

Section IV. Degenerative Diseases.
Parkinson's Disease: Molecular Insights.
The molecular basis of Alzheimer's disease.
Polyglutamine Disorders including Huntington's Disease.
Friedreich's Ataxia and Related RNA Loss-Of-Function Disorders.
DYT1, a Primary Torsion Dystonia.
Motor Neuron Disease: Amyotrophic Lateral Sclerosis.
Genetic Disorders of the Autonomic Nervous System.
Multiple sclerosis as a neurodegenerative disease.

Section V. Disorders of Excitation and Transmission.
Acquired Epilepsy: Cellular and Molecular Mechanisms.
Genetic Epilepsies.
Tourette's Syndrome.

Section VI. Disorders of Sleep and Circadian Rhythms.

Disorders of Sleep and Circadian Rhythms.

Section VII. Pain
Cronic pain as a molecular disorder.
Migraine as a cerebral ionopathy with impaired central sensory processing.

Section VIII. Peripheral Nerve Disease.
Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies.

Section IX. Neuro-Immunology.
Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis.
Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal.
Paraneoplastic Neurologic Syndromes.
Mitochondrial Disorders.

Section X. Infectious Disorders.
Molecular Neurology of HIV-1 Infection and AIDs.