Molecular Neuro-Oncology and Its Impact on the Clinical Management of Brain Tumors

ISBN-13: 9783642850417 / Angielski / Miękka / 2011 / 200 str.

O. D. Wiestler; U. Schlegel; J. Schramm

Opis

Tumors of the nervous system represent a difficult therapeutic challenge. During recent years, substantial progress has been made in characterizing genetic mechnisms involved in the formation of brain tumors. There is a lot of hope that an understanding of the molecular basis of transformation will eventually lead to specific therapeutic approaches. In this volume, leading authorities in both molecular and clinical neuro-oncology summarize recent developments in their respective fields. The first part of the book will focus on specific molecular genetic defects in neural tumors and their potential clinical significance. Part two gives an update on established and novel treatment regimens for patients with brain tumors. Several contributions will demonstrate that molecular and clinical neuro-oncology are already entangled. With its unique combination of molecular biological and clinical data, this volume provides basic researchers and clinical neuroscientists with a comprehensive update in both disciplines.

Spis treści

Molecular Neuro-oncology.- Human Neuroblastoma: Amplification of the N-myc Oncogene and Loss of a Putative Cancer-Preventing Gene on Chromosome 1p.- Epidermal Growth Factor Receptor Gene and Its Transcripts in Glioblastomas.- Type and Frequency of p53 Mutations in Tumors of the Nervous System and Its Coverings.- Astrocytic Gliomas: Characterization on a Molecular Genetic Basis.- Prognostic Relevance of Transforming Genes.- Oncogene Transfer into the Brain.- The O-2A Lineage: From Rats to Humans.- Clinical Neuro-oncology.- The Anti-Hu Syndrome: A Model Paraneoplastic Disorder.- Radiosurgery/Stereotactic External Beam Radiotherapy for Malignant Brain Tumours: The Royal Marsden Hospital Experience.- Interstitial Implant Radiosurgery of Brain Tumors: Radiobiology, Indications, and Results.- Interstitial Brachytherapy of Malignant Gliomas: The Memorial Sloan-Kettering Cancer Center Experience.- Aggressive Oligodendroglioma: A Chemosensitive Tumor.- Chemotherapy of Malignant Gliomas.- Interstitial Chemotherapy with Sustained-Release Polymer Systems for the Treatment of Malignant Gliomas.- Primary Central Nervous System Lymphoma.- Epidermal Growth Factor Receptor Expression in Human Malignant Glioma: In Vitro and In Vivo Effects of Application of Monoclonal Antibodies to the Epidermal Growth Factor Receptor.- Target Cell Induced T Cell Activation with Bispecific Antibodies: A New Concept for Tumor Immunotherapy.