Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology

ISBN-13: 9781138035157 / Angielski / Twarda / 2018 / 610 str.

Deepak Chitkara; Anupama Mittal; Ram I. Mahato

Opis

The field of molecular medicine covers the medical interventions targeting molecular structures and mechanisms that are involved in disease progression. In cancer, several molecular mechanisms have been shown to impact its progression, aggressiveness and chemoresistance. Increasing evidence demonstrates the role of nanotechnology and outcome of molecular therapy. Several books have discussed molecular biology and mechanisms involved in cancer, but this text gives an account of molecular therapeutics in cancer relating to advancements of nanotechnology. It provides a description of the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology.

Spis treści

Section I: Nanotechnology-Based Approaches to Target Cancer 1. Nanomedicines for Cancer 2. Effect of Nanocarrier Size/Surface on Molecular Targeting in Cancer 3. Nanocarrier Systems for Anticancer Drug Delivery at the Subcellular Level 4. Chemo-Resistance Reversal Using Nanomedicines 5. Multifunctional Dendrimers as Cancer Nanomedicines: Peptide-Based Targeting 6. Targeting the Tumor Microenvironment 7. Novel Nanoparticulate Drug Delivery Systems for Active Ingredients of Traditional Chinese Medicine in Cancer Therapy Section II: Imaging Technologies in Cancer 8. Noninvasive Imaging in Clinical Oncology: A Testimony of Current Modalities and a Glimpse into the Future 9. Multifunctional Nanocarriers as Theranostic Systems for Targeting Cancer 10. Emerging Nanotechnologies for Cancer Immunodiagnosis and Cancer Immunotherapies Section III: Oligonucleotides and Gene-Based Therapies 11. Nucleic Acid Nanotherapeutics 12. Long Non-Coding RNA and Cancer 13. miRNA Therapeutics to Target Multiple Molecular Pathways: Current Status, Challenges, and Future Prospects 14. Alliance of Lipids with siRNA: Opportunities and Challenges for RNAi Therapy 15. Lipid Nanocarriers for RNAi-Based Cancer Therapy 16. Advancements in Polymeric Systems for Nucleic Acid Delivery 17. Self-Assembling Programmable RNA Nanoparticles: From Design and Characterization to Use as an siRNA Delivery Platform 18. DNA Repair and Epigenetics in Cancer 19. Genomic Engineering Utilizing the CRISPR/Cas System and Its Application in Cancer