Molecular Mechanisms of Cancer

ISBN-13: 9789048175055 / Angielski / Miękka / 2010 / 660 str.

Georg F. Weber

Opis

This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.

Recenzje

From the reviews:

"The book under review is definitely the best book on Molecular Biology of Cancer. ... It is very well written, clear, with several examples and of easy comprehension. I suggest this book to you if you are interested in to study all the tricks of the molecular mechanisms of cancer. ... The books is a necessary reading for all medical and biological students interested in Cancer and it will become the reference on the subject." (Philosophy, Religion and Science Book Reviews, bookinspections.wordpress.com, December, 2013)

Spis treści

CONDENSED TABLE OF CONTENTS Introduction Section I. General Mechanisms Of Transformation 1. Theories of Carcinogenesis 2. Physiologic Correlates of Malignancy Section II. Alterations Intrinsic to the Tumor Cells 3. Cell Division and Survival 4. Cellular Senescence 5. Invasiveness Section III. Mechanisms of Regulation Of Cancer Related Genes 6. DNA Repair 7. Epigenetic Regulation of Cancer Associated Gene Products 8. Interaction of the Groups of Cancer Related Gene Products Section IV. Interactions between Host and Tumor 9. Structural Growth Control 10. The Organ Preference of Metastasis Formation 11. Angiogenesis 12. Interactions with The Immune System 13. Endocrine Dysregulation 14. Dormancy and Minimal Residual Disease Section V. Molecular Mechanisms of Individual Cancers 15. Epithelial Tumors 16. Hematologic Malignancies 17. Mesenchymal Tumors 18. Neurologic Tumors 19. Tumors of Serous Cavities 20. Embryonic Tumors

O autorze

Molecular Mechanisms of Cancer describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers. This book is an essential resource for researchers, graduate students and oncologists. It will also aid in drug discovery by identifying molecular targets.