Molecular Mechanisms in Legionella Pathogenesis

ISBN-13: 9783662523001 / Angielski / Miękka / 2016 / 295 str.

Hubert Hilbi

Opis

Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.

Spis treści

From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts

Pedro Escoll, Monica Rolando, Laura Gomez-Valero and Carmen Buchrieser

The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors

Gil Segal

Facets of small RNA-mediated regulation in Legionella pneumophila

Hana Trigui, Nilmini Mendis, Laam Li, Mariam Saad and Sebastien P. Faucher

Type II secretion and Legionella virulence

Nicholas P. Cianciotto

Effector translocation by the Legionella Icm/Dot type IV secretion system

Jiazhang Qiu and Zhao-Qing Luo

Modulation of small GTPases by Legionella

Roger S. Goody and Aymelt Itzen

Host lipidation: A mechanism for spatial regulation of Legionella effectors

Stanimir S. Ivanov and Craig Roy

Phosphoinositides and the Legionella pathogen vacuole

Ina Haneburger and Hubert Hilbi

Legionella phospholipases implicated in virulence

Katja Kuhle and Antje Flieger

Cytotoxic glucosyltransferases of Legionella pneumophila

Yury Belyi, Thomas Jank and Klaus Aktories

Modulation of the ubiquitination machinery by Legionella

Andree Hubber, Tomoko Kubori and Hiroki Nagai

Host signal transduction and protein kinases implicated in Legionella infection

Andrew D. Hempstead and Ralph R. Isberg

Mouse models of Legionnaires´ disease

Andrew S Brown, Ian R van Driel and Elizabeth L Hartland