Molecular Mechanisms That Orchestrate the Assembly of Antigen Receptor Loci: Volume 128

ISBN-13: 9780128032961 / Angielski / Twarda / 2015 / 454 str.

Murre, Cornelis

Opis

Molecular Mechanisms That Orchestrate the Assembly of Antigen Receptor Loci, the latest volume in the Advances in Immunology series focuses on the generation of an effective immune response to invading pathogens As B and T lymphocytes are characterized by the expression of antigen receptors that specifically recognize determinants expressed on pathogens, this volume discusses how antigen receptors are synthesized in B and T lymphocytes.

• Focuses on the generation of an effective immune response to invading pathogens
• Contains contributions from leading authorities
• Informs and updates on all the latest developments in the field of immunology

Spis treści

1. Regulation and Evolution of the RAG Recombinase
   Grace Teng and David G. Schatz
2. Chromatin Interactions in the Control of Immunoglobulin Heavy Chain Gene Assembly
   Gita Kumari and Ranjan Sen
3. Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci
   Anja Ebert, Louisa Hill and Meinrad Busslinger
4. Long Range Regulation of V(D)J Recombination
   Charlotte Proudhon, Bingtao Hao, Ramya Raviram, Julie Chaumeil and Jane A. Skok
5. Dynamic Control of Long-range Genomic Interactions at the Immunoglobulin ? Light Chain Locus
   Claudia Ribeiro de Almeida, Rudi W. Hendriks and Ralph Stadhouders
6. Regulation of Tcrb Gene Assembly by Genetic, Epigenetic, and Topological Mechanisms
   Kinjal Majumder, Craig H. Bassing and Eugene M. Oltz
7. Chromatin Dynamics and the Development of the TCRa and TCRd  Repertoires
   Zachary Carico and Michael S. Krangel
8. Long-range Control of V(D)J Recombination & Allelic Exclusion: Modeling Views
   Pernelle Outters, Sébastien Jaeger, Nancy Zaarour and Pierre Ferrier
   

O autorze

Cornelis Murre performed his graduate work as a joined program with the University of Leiden at Harvard Medical School. He was a postdoctoral fellow at the Whitehead Institute. He is a Searle Scholar and the recipient of the National Institutes of Health Merit Award. Currently he is a Distinguished Professor in the Biological Sciences at the University of California, San Diego.

Dr. Murre has focused his research on the regulation and function of helix-loop-helix (HLH) proteins in stem cells, lymphocyte development and homeostasis. Control of tissue-specific gene expression during B and T lymphocyte development, cell growth, cell death and aging are the prominent themes in his research. Specifically the Murre laboratory has shown that subset of HLH proteins, the "E proteins", contribute to B lineage- and T lineage- specific gene expression programs, regulate lymphocyte survival and cellular proliferation, activate the rearrangement of antigen receptor genes, and control progression through critical developmental checkpoints. In more recent studies they have constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate. Currently, his studies are focused on physical mechanisms that underpin the generation of antigen receptor diversity.