Molecular Imaging in Oncology

ISBN-13: 9780849374173 / Angielski / Twarda / 2008 / 776 str.

Pomper G. Pomper; Martin G. Pomper; Martin G. Pomper

Opis

With molecular imaging becoming one the fastest growing topics in medical schools, Informa Healthcare presents Molecular Imaging in Oncology, the first comprehensive reference on molecular imaging in oncology. Giving clinicians and researchers a greater understanding of the current field, this text covers:

• instrumentation and techniques
• cancer imaging
• probe design
• molecular genetic imaging
• cellular processes
• clinical translation

Filled with over 500 images, of which more than 50 are in color, illustrating diagnostic and therapeutic capabilities of molecular imaging in cancer, this text outlines all procedures for radiologists, radiology physicists, and radiation oncologists in a concise, single-source guide.

Spis treści

Foreword. A Word on Molecular Imaging. Preface. Tumor Biology. Introduction to Molecular Biology. Methods in Molecular Biology. The Analysis of Complex Datasets: Challenges and Opportunities. Molecular PET Imaging Instrumentation and Techniques. Molecular SPECT Imaging Instrumentation and Techniques. Ultrasound Instrumentation and Techniques. Oncological Applications of MR Spectroscopy. Physiological and Functional Imaging with CT: Techniques and Applications. Multi-Modality Imaging Instrumentation and Techniques. Targeted Agents for MRI. High-throughput Screening for Probe Development. Radiopharmaceuticals for SPECT. Radionuclides for Therapy. CEST Contrast Agents. Optical Imaging Probes. Nanoparticles in Molecular Imaging. Long-lived and Unconventional PET Radionuclides. The Design of New Imaging Agents Using Positron Emitting Radionuclides as the Reporter. Targeted Radiolabeled Receptor-avid Peptides. Targeted Ultrasound Contrast Agents. Quantification in Small Animal PET and SPECT Imaging. In Vivo Imaging Mouse Models of Breast Cancer. Basics of Small Animal Handling for In Vivo Imaging. Imaging Cellular Networks and Protein-Protein Interactions In Vivo. Novel Reporter Probes for HSV1-tk Gene Expression. Clinical Potential of Gene Expression Imaging. Overview of Molecular-genetic Imaging. Imaging Angiogenesis. Imaging Apoptosis. Imaging Cell Trafficking with MR Imaging. General Considerations for Labeling and Imaging of Cells. Molecular Imaging of the Extracellular Matrix and Lymphatic Phenomena in Tumors. Nuclear Imaging of Adoptive Cell Therapies. Optical Techniques for Imaging of Cell Trafficking. Radioimmunotherapy of Cancer. Monoclonal Antibody Imaging. Advanced MRI Imaging in Cancer: Translating Basic Science to Practice. Molecular Imaging of Breast Carcinoma. FDG PET/CT Imaging. Clinical uses and opportunities. Molecular Imaging of Prostate Cancer. Anticancer Drug Development with Optical Imaging. Drug Development with Radiopharmaceutica

O autorze

MARTIN G. POMPER is Professor of Radiology, Director of the Small Animal Imaging Resource Program, and Associate Director of the In Vivo Cellular and Molecular Imaging Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. He received his Ph.D. in organic chemistry and M.D. from the University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. Dr. Pomper serves on the editorial boards of several publications and is currently Editor-in-Chief of Molecular Imaging. His research interests include the development of new probes and techniques for molecular imaging of cancer, focusing on radiopharmaceutical development and clinical translation. He is the immediate past president of the Molecular Imaging Center of Excellence of the SNM.

JURI G. GELOVANI is Professor and Chairman, Department of Experimental Diagnostic Imaging and Director, Center for Advanced Biomedical Imaging Research (CABIR) at the University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA. He received his M.D. and Ph.D. in clinical Neurosurgery & Neuroimaging from the University of Tartu, Tartu, Estonia. Prof. Gelovani is the pioneer of non-invasive molecular-genetic imaging using radiotracers. He is one of the co-founders of the field of modern molecular imaging. His research is dedicated to improving cancer detection and non-invasive molecular-genetic profiling, imaging-based selection of novel individualized anti-cancer therapies and monitoring their efficacy, including targeted small molecular and nanopartical based therapies, genetic and cellular therapies. He is leading the development of a premiere research program aimed at the discovery of novel and more specific chemical, genetic, and cellular tracers for imaging different tumor-specific targets, while continuing to mentor and teach graduate and postgraduate students. In 2008, Prof. Gelovani served as President of the Society for Molecular Imaging, which he had co-founded, and as th