Molecular Imaging and Targeted Therapy: Radiopharmaceuticals and Clinical Applications

ISBN-13: 9783031232039 / Angielski / Twarda / 2023 / 800 str.

Shankar Vallabhajosula

Opis

This book, now published in its second edition, covers a wide range of topics relating to the use of radiopharmaceuticals. The basics of nuclear chemistry, radiochemistry, and radiopharmacology are considered in detail, regulatory issues are reviewed, and potential applications in drug development, translational medicine, clinical diagnostics, and targeted therapy are discussed. Compared with the first edition, the chapters on targeted therapy with alpha- and beta-emitting radiopharmaceuticals and theranostics are completely new. Other chapters have been updated and revised as necessary.Radioisotope-based molecular imaging probes (radiopharmaceuticals) provide unprecedented insights into biochemistry and function in both normal and diseased states of living systems, with unbiased in vivo measurements of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology, including functional magnetic resonance imaging, can provide such high sensitivity and specificity at a tracer level. This book, written by an experienced radiochemist and scientist, offers valuable insights into the full range of applications of this technology.

Spis treści

1.    Molecular Imaging and Targeted Radionuclide Therapy: Introduction
2.    Science of Atomism: A Brief History
3.    Atoms and Radiation
4.    Radioactivity
5.    Radioactivity Detection: PET and SPECT Scanners
6.    Chemistry: Basic Principles Cell and Molecular Biology
7.    Production of Radionuclides
8.    Radiopharmaceuticals for Molecular Imaging
9.    Radiohalogens for Molecular Imaging (Fluorine and Iodine)
10.  Organic Radionuclides for Molecular Imaging (C, N, and O)
11.  Metal Radionuclides for Molecular Imaging
12.  Pharmacokinetics and Modeling
13.  Molecular Imaging in Oncology
14.  Molecular Imaging in Neurology                 
15.  Molecular Imaging in Cardiology
16.  Radiopharmaceuticals for Therapy                   
17.  Chemistry of Therapeutic Radionuclides
18.  Radiolabeled Antibodies for Imaging and Targeted Therapy
19.  Design of Radiolabeled Peptide Radiopharmaceuticals:
20.  Theranostics in Neuroendocrine Tumors  
21.  Theranostics in Prostate Cancer 
 

O autorze

Dr. Vallabhajosula attended high school in the small town of Bobbili, Andhra Pradesh, India. He graduated from Andhra University with a BS and MS in Pharmacy and subsequently obtained his Ph.D. from the University of Southern California, in 1980. After receiving the doctorate, he first worked at Mount Sinai Medical Center in New York and since 1997 has been a Professor of Radiochemistry and Radiopharmacy in Radiology at Weill Cornell Medicine of Cornell University and New York Presbyterian Hospital. He is now the Professor Emeritus in Radiology at Weill Cornell Medicine.