Molecular Genetics of Mycobacteria

ISBN-13: 9781555818838 / Angielski / Twarda / 2014 / 832 str.

Opis

A comprehensive collection of perspectives by experts in mycobacterial molecular biology Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today. Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge. Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition,

• Discusses key areas of current research in mycobacterial genetics
• Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis
• Presents genetic approaches for manipulating M. tuberculosis
This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

Spis treści

ContributorsPrefaceI. Genomes, Genomics, and Genetic Exchange1. Gene Transfer In Mycobacterium Tuberculosis: Shuttle Phasmids to EnlightenmentWilliam R. Jacobs, Jr.2. Mycobacterial Pathogenomics and EvolutionDaria Bottai, Timothy P. Stinear, Philip Supply, and Roland Brosch3. BCG VaccinesVanessa Tran, Jun Liu, and Marcel A. Behr4. Distributive Conjugal Transfer: New Insights into Horizontal Gene Transfer and Genetic Exchange in MycobacteriaKeith M. Derbyshire and Todd A. Gray5. Molecular Genetics of MycobacteriophagesGraham F. Hatfull6. Genetics of Phage LysisMadalena PimentelII. Gene Expression and Regulation7. Sigma Factors: Key Molecules In Mycobacterium Tuberculosis Physiology and VirulenceRiccardo Manganelli8. Transcription Factor Binding Site Mapping Using ChIP-SeqSuma Jaini, Anna Lyubetskaya, Antonio Gomes, Matthew Peterson, Sang Tae Park, Sahadevan Raman, Gary Schoolnik, and James Galagan9. Noncoding RNA in MycobacteriaKristine B. Arnvig, Teresa Cortes, and Douglas B. Young10. Two-Component Regulatory Systems of MycobacteriaTanya Parish11. Regulated Expression Systems for Mycobacteria and Their ApplicationsDirk Schnappinger and Sabine EhrtIII. The Mycobacterial Proteome12. Mycobacterium Tuberculosis In The Proteomics EraMartin Gengenbacher, Jeppe Mouritsen, Olga T. Schubert, Ruedi Aebersold, and Stefan H. E. Kaufmann13. Structural Annotation of the Mycobacterium tuberculosis ProteomeNagasuma Chandra, Sankaran Sandhya, and Praveen Anand14. Cyclic AMP Signaling in MycobacteriaGwendowlyn S. Knapp and Kathleen A. McDonoughIV. Metabolism15. The Physiology and Genetics Of Oxidative Stress In MycobacteriaBridgette M. Cumming, Dirk Lamprecht, Ryan M. Wells, Vikram Saini, James H. Mazorodze, and Adrie J. C. Steyn16. Metabolomics of Central Carbon Metabolism in Mycobacterium tuberculosisAnthony D. Baughn and Kyu Y. Rhee17. Mycobacterial LipidomicsEmilie Layre, Reem Al-Mubarak, John T. Belisle, and D. Branch Moody18. Genetics of Mycobacterial Trehalose MetabolismRainer Kalscheuer and Hendrik Koliwer-Brandl19. Metallobiology of TuberculosisG. Marcela Rodriguez and Olivier Neyrolles20. Energetics of Respiration and Oxidative Phosphorylation in MycobacteriaGregory M. Cook, Kiel Hards, Catherine Vilchèze, Travis Hartman, and Michael BerneyV. Genetics of Drug Resistance21. Molecular Basis of Drug Resistance In Mycobacterium TuberculosisKeira A. Cohen, William R. Bishai, and Alexander S. Pym22. Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and CausalitiesCatherine Vilchèze and William R. Jacobs, Jr.23. The Molecular Genetics of Fluoroquinolone Resistance in Mycobacterium tuberculosisClaudine Mayer and Howard Takiff24. Mechanisms of Pyrazinamide Action and ResistanceYing Zhang, Wanliang Shi, Wenhong Zhang, and Denis Mitchison25. Genetic Strategies for Identifying New Drug TargetsAndrej Trauner, Christopher M. Sassetti, and Eric J. RubinVI. Genetics of Membrane and Cell Wall Biosynthesis26. Genetics of Peptidoglycan BiosynthesisMartin S. Pavelka, Jr., Sebabrata Mahapatra, and Dean C. Crick27. Genetics of Mycobacterial Arabinogalactan and Lipoarabinomannan AssemblyMonika Jankute, Shipra Grover, Helen L. Birch, and Gurdyal S. Besra28. Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipidsMamadou Daffé, Dean C. Crick, and Mary Jackson29. The Molecular Genetics of Mycolic Acid BiosynthesisJakub PaweBczyk and Laurent KremerVII. Genetics of Macromolecular Biosynthesis30. Nucleotide Metabolism and DNA ReplicationDigby F. Warner, Joanna C. Evans, and Valerie Mizrahi31. Double-Strand DNA Break Repair in MycobacteriaMichael S. Glickman32. The Pup-Proteasome System of MycobacteriaNadine J. Bode and K. Heran Darwin33. Mycobacterium tuberculosis Serine/Threonine Protein KinasesSladjana Prisic and Robert N. HussonVIII. The Mycobacterial Lifestyle, Persistence, and Macrophage Survival34. The Spectrum of Drug Susceptibility in MycobacteriaBree B. Aldridge, Iris Keren, and Sarah M. Fortune35. The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell-Derived PressuresDavid G. Russell, Wonsik Lee, Shumin Tan, Neelima Sukumar, Maria Podinovskaia, Ruth J. Fahey, and Brian C. VanderVen36. Evasion of Innate and Adaptive Immunity by Mycobacterium tuberculosisMichael F. Goldberg, Neeraj K. Saini, and Steven A. Porcelli37. Mycobacterial BiofilmsJacobs P. Richards and Anil K. OjhaIndex