Molecular Genetics of Cardiac Electrophysiology

ISBN-13: 9780792378297 / Angielski / Twarda / 2000 / 378 str.

Charles I. Berul; Jeffrey A. Towbin; C. Berul

Opis

The field of molecular genetics has rapidly expanded and is becoming increasingly important in the area of cardiac electrophysiology. The genetic basis of cardiac conduction disturbances and arrhythmogenesis is now recognized as a critical factor in disease pathology. Inherited structural and electrical heart diseases are being elucidated using molecular biological approaches, with differentiation of gene-specific diagnosis, prognostication, and therapeutics. Unique genetically-engineered animal models of hereditary arrhythmias and heart disease are being developed and utilized for detailed characterization of the cardiac conduction system.
The goal of this book is to provide the adult and pediatric cardiologist, electrophysiologist, geneticist, internist, pediatrician, and trainee with a comprehensive review and update of this new field involving the molecular genetics of cardiac electrophysiology.

Spis treści

Preface. 1. Overview: Genetics of Cardiac Electrophysiology; J.A. Towbin, C.I. Berul. Section I: Experimental Investigation of Inherited Electrophysiological Disorders. 2. Single-Cell Electrophysiology & Ion Channelopathies; C. Lopes, et al. 3. Animal Models of Inherited Electrophysiologic Diseases; A. Rakhit, C.I. Berul. 4. Optical Mapping of Arrhythmias; G.E. Morley, et al. 5. Connexins and Conduction; D. Lerner, J. Saffitz. Section II: Hereditary Arrhythmias. 6. Hereditary Supraventricular Tachycardias; P.Y. Jay, C.I. Berul. 7. Familial Atrial Fibrillation; R. Brugada, R. Roberts. 8. The Molecular Cardiology of Heart Block; R.M. Hamilton. Section III: Ion Channel Mutations with Clinical Electrophysiologic Consequences. 9. Congenital Long QT Syndromes; G.M. Vincent, K. Timothy. 10. Molecular Genetics of the Acquired Long QT Syndrome; D. Roden. 11. Brugada Syndrome Genetics; J.A. Towbin, et al. Section IV: Inherited Cardiomyopathies with Arrhythmias. 12. Familial Hypertrophic Cardiomyopathy Genetics; L.M. Bevilacqua, C.I. Berul. 13. Familial Dilated Cardiomyopathy; J.A. Towbin, N.E. Bowles. 14. Glycogen Storage Diseases; M. Irons, E.R. Elias. 15. Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy; F.I. Marcus, P. Ott. 16. Cardiac Disease in Duchenne & Becker Muscular Dystrophies: The Dystrophinopathies; L.B. Smoot, G. Cox. 17. Myotonic Muscular Dystrophy Genetics and Cardiac Sequelae; S. Reddy, C.I. Berul. Section V: Inherited Structural Heart Diseases Associated with Arrhythmias. 18. Genetic Causes of Atrial Septal Defects; K. Patton, C.E. Seidman. 19. Holt-Oram Syndrome and the TBX5 Transcription Factor in Cardiogenesis; C.J. Hatcher, C.T. Basson. 20. Inherited Structural Heart Diseases Associated With Arrhythmias: Defects in Laterality; B.S. Ticho, R. Van Praagh. 21. Marfan Syndrome and Related Disorders of Fibrillin; R.V. Lacro. 22. The Molecular Genetics of Conotruncal Defects; E. Goldmuntz. Index.