Molecular Genetics: 4. Wissenschaftliche Konferenz Der Gesellschaft Deutscher Naturforscher Und Ärzte Berlin 1967

ISBN-13: 9783540042761 / Angielski / Miękka / 1968 / 343 str.

Heinz G. Wittmann; Heinz Schuster

Opis

A small informal symposium on "Molecular Genetics" was organized by us on behalf of the "Gesellschaft Deutscher Naturforscher und Arzte" and took place in Berlin in October 1967. There were about 40 partici- pants from Europe and the United States. Molecular Genetics represents today an extraordinarily comprehensive research field. Therefore the organizers of the symposium had the choice either of limiting the meeting to a particular topic or of covering a wider selection of current problems. The latter alternative was chosen. The fields of research of the participants covered the broad range of scientific problems in which molecular genetics is nowadays involved: Genetic code; chemistry and biosynthesis of proteins; mutation, modification and reactivation of nucleic acids; biochemistry of regulation; comple- mentation; structure; replication and function of viruses, etc. The meeting took place in the Hotel Schweizerhof where the partici- pants were also accommodated. This permitted close contact between the participants outside of the official program and allowed informal discussions, which started during the meetings, to be continued after- wards. Owing to the informal nature of these discussions, only a part of them could be included in this book. Berlin, September 1968 H. G. WITTMANN H. SCHUSTER Contents List of Participants . . . . . . . . . . .... VII I. Structure and Function of Ribosomes; Complementation Complementation and Dominance Relationsship between Protein Subunits. By J. R. S. FINCHAM. . . . . . . . . . . . . . . Ribosomal Proteins of E. coli and Yeast. By E. KALTSCHMIDT, V. RUDLOFF, G. STOFFLER, A. CHERSI, M. DZIONARA, D. DOlIIER, and H. G. WITTMANN . . . . . . . . . . . . . . .. . . 5 .

Spis treści

I. Structure and Function of Ribosomes; Complementation.- Complementation and Dominance Relationsship between Protein Subunits.- Ribosomal Proteins of E. coli and Yeast.- Studies on Purified E. coli Ribosomal Proteins.- Structural Studies on Ribosomal Proteins: Peptides from Cyanogen Promide Cleavage and Tryptic Digestion.- The Role of 30 S Ribosomal Subunits in Initiation of Protein Synthesis.- Structure and Function of Ribosomes: Studies on Dissociation and Reconstitution of Ribosomal Particles.- The Formation of the Peptide Bond on Ribosomes.- II. Codons; Protein Synthesis.- Synthesis of Polyphenylalanine in a Cell-free System from E. coli A 19: Ribosomal Binding Sites, Initiation with Formyl-methionyl-tRNA, and Codon-Interaction of Aminoacyl-Trna.- Modification of DNA-Dependent RNA-Polymerase in T 4 — infected E. coli.- Genetic Control of Translation of Nonsense Triplets.- The Recognition of Anomalous Triplet-Codons by Aminoacyl-tRNA.- Structure and Cellular Function of Aminoacyl Ribonucleic Acid Synthetases.- The Formation of Phenylalanyl-tRNA-synthetase Crossreacting Material in Temperature sensitive Mutants of E. coli.- III. Modification, Reactivation, Mutation.- Host-Controlled Modification of DNA.- Genetic Recombination Induced by Ultraviolet Light.- Repair of DNA in a Mutant of E. coli Temperature-Sensitive in DNA Synthesis.- Prophage Attachment and Detachment: Comparison of Phages P 2 and ?.- Mutants of Serratia Marcescens Defective or Superactive in the Release of a Nuclease.- IV. Regulation.- In vivo Studies of Inducer-Repressor Interactions.- Strong-Polar Mutations in the Galactose Operon of E. coli.- The Role of the Promoter Site in Gene Expression.- Regulation of Pyruvate Dehydrogenase Synthesis: Substrate Induction.- Transcription in Amino Acid Starved Bacteria.- Hemoglobins of Chironomus tentans and C. pallidivitatus: Biochemical and Cytological Studies.- V. Virus.- Gene Functions and Genetics of Phage S 13.- Distribution of Thymidilate Incorporation into the DNA of X 174-Infected Triphosphate Permeable Cells.- Primary Structure of fd Coat Protein. Comparative Studies with Proteins of Phages fl, M 13 and ZJ-2.- Control Mechanisms in T 4 Infection: Studies on the Exclusion of the RNA Phage M 12 in Mixedly Infected Cells.- Defective Plant Viruses.- Gene Functions of Influenza Virus.