Molecular Epidemiology: Principles and Practices

ISBN-13: 9780126323467 / Angielski / Miękka / 1998 / 588 str.

Paul A. Schulte (National Institute for Occupational Safety; U.S.A.) New York Frederica P. Perera (Columbia University

Opis

This groundbreaking work, now available in paperback, has helped to shape the emerging discipline of molecular epidemiology. Molecular Epidemiology has proven useful to epidemiologists unfamiliar with the terminology and techniques of molecular biology as well as to the molecular biologist working to understand the determinants of human disease and to use that information to control disease. This book demonstrates how molecular epidemiology utilizes the same paradigm as traditional epidemiology in addition to using biological markers to identify exposure, disease, or susceptibility.

Recenzje

"The book is an excellent review of the crucial issues related to the incorporation of new markers of exposure, disease, or susceptibility into epidemiologic investigations... This book is an excellent resource for all researchers involved in the quest to understand the determinants of disease and apply this knowledge to the maintenance of the health of the public."
--SCIENCE

Spis treści

Contributors.
Preface.
General Principles:
A Conceptual and Historical Framework for Molecular Epidemiology, P.A. Schulte.
Molecular Biology in Epidemiology, R. Hurst and J.Y. Rao.
Validation, P.A. Schulte and F.P. Perera.
Technical Variability in Laboratory Data, P. Vineis, P.A. Schulte, R.F. Vogt, Jr..
Biological Monitoring and Pharmacokinetics Modeling for the Assessment of Exposure, P.O. Droz.
Design Considerations in Molecular Epidemiology, P.A. Schulte, N. Rothman, and D. Schottenfeld.
Statistical Issues and Procedures, V.S. Hertzberg and E. Russek-Cohen.
Biological Specimen Banks: A Resource for Molecular Epidemiologic Studies, D.M. Winn and E.W. Gunter.
Interpretation and Communication of Results, P.A. Schulte.
Use of Biomarkers in Risk Assessment.
Practical Applications, D. Hattis and K. Silver.
Practical Applications:
Carcinogenesis, F.P. Perera and R. Santella.
Infectious Disease, L.H. Harrison and D.E. Griffin.
Cardiovascular Disease, P.A. Schulte, N. Rothman, and M.A. Austin.
Genetic Disease, M.J. Khoury and J.S. Dorman.
Biologic Markers in the Epidemiology of Reproduction, G.K. Lemasters and P.A. Schulte.
Immune Markers in Epidemiologic Field Studies, R.F. Vogt, Jr. and P.A. Schulte.
Biomarkers of Pulmonary Disease, M.S. Tockman, P.K. Gupta, N.J. Pressman and J.L. Mulshine.
Pulmonary Disease.
Biologic Markers in the Genitourinary System, G.P. Hemstreet, III, R.E. Hurst and N.R. Asal.
Neurologic Disease, J.D. Griffith and V.F. Garry.
Practical Applications of Biomarkers in the Study of Environmental Liver Disease, C.H. Tamburro and J.L. Wong.
Biomarkers of Musculoskeletal Disease, J.P. Mastin, G.M. Henningsen, and L.J. Fine.
Epilogue, N. Rothman.
Index.