Molecular Endocrinology of Cancer: Volume 1, Part 2, Endocrine Therapies

ISBN-13: 9780521460675 / Angielski / Twarda / 1996 / 442 str.

London) Jonathan Waxman (Royal Postgraduate Medical School

Opis

One third of human cancers have a hormonal basis. Breast cancer, the most common cancer of women, is increasing in incidence in many countries, as, in epidemic proportions, is prostate cancer, the second most common cancer of men. Concurrently, the development of molecular biology has led to a refinement of the definition of hormones to include the complex interaction between tumour cells and both locally and distantly secreted factors. This volume in the series Cancer: Clinical Science in Practice considers the many aspects of hormonally dependent cancer, including the molecular basis for the autocrine and paracrine regulation of cancer, molecular strategies for cancer detection, preventive strategies in limiting the epidemic of hormonally related cancers, and new treatment approaches. Concise and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the application of biomedical science to the understanding and management of cancer.

Spis treści

Contributor list; Part I. The Regulation of Cancer: 1. The type 1 growth factor receptor family, their ligands and their role in human cancers T. Rajkumar and W. J. Gullick; 2. The fibroblast growth factor family and their receptors Pita Enriquez Harris and John K. Heath; 3. The biological role of transforming growth factor beta in cancer development Bradley A. Arrick and Rik Derynck; 4. Bombesin and its receptor Michael J. Seckl and Enrique Rozengurt; 5. Gonadotrophin-releasing hormone and its receptor Karin A. Eidne and Lorraine Anderson; 6. Cytokines T. Hamblin; Part II. The Prevention of Endocrine-Dependent Tumours: 7. Familial Cancer Audrey D. Goddard and Donald M. Black; 8. Diet Peter Boyle and Patrick Maisonneuve; 9. Breast cancer: new biological approaches to treatment Robert B. Dickson and Robert Clarke; 10. The biological basis for the treatment of prostate cancer Jonathan Waxman, Andrew Stubbs and Hardev Pandha; 11. Carcinoid tumours S. Bloom and P. Hammond; Part III. Endocrine Complications of Cancer Treatment: 12. Humoral hypercalcaemia John J. Wysolmerski and Arthur E. Braodus; 13. Anaemia of cancer Carole B. Miller and Jerry L. Spivak; Index.