Molecular Biology of Hematopoiesis 6

ISBN-13: 9780306461361 / Angielski / Twarda / 1999 / 404 str.

Opis

This volume focuses on molecular genetic/drug manipulation affecting the biology of hematopoiesis, leukemia, and other related cancers as well as on hemoglobinopathy, aplastic anemia, pediatric oncology, growth factors in transplantation, hematologic malignancies, solid tumor chemotherapy and drug resistance, gene expression and gene transfer and on viruses and hematopoiesis. Some of the topics covered include: new information on BMT for autoimmune disease and organ transplants, new findings on gene therapy/transfer into HSC, new studies on gene transfer into primates, new information on gene transfer, scientific and clinical results of iron overload and hematopoiesis, iron and erythropoiesis and search for candidate genes, molecular diagnosis and chemotherapy, use of cord blood stem cells for transplantation, and new information on transcriptional factors regulating hematopoiesis.

Spis treści

Part I: Hematopoietic Stem Cell Development. 1. The Development of Hematopoietic Cell Transplantation and its Application to Organ Transplantation and Autoimmune Diseases; E.D. Thomas. 2. Hemopoietic Stem Cells - Normal and Abnormal; S. Ikehara. 3. Immunity and Tolerance are Related, and Governed by Antigen Migration and Localization; T.E. Starzl, et al. 4. Genetic Approaches to the Investigation of the Mechanisms of Hematopoietic Progenitor Cell Mobilization into the Blood; A.W. Roberts, et al. 5. Role of Hematopoietic Growth Factors on the Ex-Vivo Expansion of Primitive Cord Blood Stem Cells; M. Aglietta, et al. 6. Thymus-Independent T Cell Differentiation In Vitro; M. Sanchez, et al. 7. Immunogenetics Problems in Cord Blood Transplantation; F. Poli, et al. Part II: Update on Solid Tumor and Bone Marrow Transplantation. 8. High-Dose Chemotherapy for Breast Cancer in Europe: From Fashion to Randomization; G. Rosti, et al. 9. Differential Enhancement of Graft-versus-Host (GVH) and Graft-versus-Leukemia (GVL) Reactions by Interleukin-12 (IL-12); M. Schmitt, et al. 10. De Novo and Secondary AML Cells Differ in Their Kinetic Response to HGF Priming; M.A. Smith, et al. 11. Clinical Factors Contributing to the Pace of Engraftment after Allogeneic and Autologous Stem Cell Transplantation: Multivariate Analysis; G.J. Elfenbein. 12. Clinical Relevance of Bone Marrow Histologic Examination in HIV-Infected Patients; S. Cantoni, et al. 13. Molecular Biology of Childhood Solid Tumors; Promises Maintained and Promises Postponed; C. Dominici, P.Kogner. 14. Molecular Genetics of Wilms Tumor; K. Pritchard-Jones. 15. Genetic Heterogeneity in Ewing Tumors and Neuroblastomas; P.F. Ambros, et al. 16. Mechanisms of Retinoid Inhibition of Cell Proliferation in Neuroblastoma; T. Matsuo, C.J. Thiele. 17. Combination of Carboplatin and Etoposide in the Management of Intraocular Retinoblastoma; M.A. Castello, et al. 18. Hyper-IL-6 (H-IL-6), a Fusion Protein of Soluble IL-6 Receptor (sIL-6R) and Interleukin-6 (IL-6), Acts Synergistic with Thrombopoietin (TPO) and Stem Cell Factor (SCF) in Expanding Megakaryocyte Progenitors from Human CD34++/CD90+ Cell; J. Birkmann, et al. 19. Towards Vaccination with Defined Tumor Antigens? P. van de Bruggen, et al. Part III: Myloproliferative Disorders: Basic and Clinical Update. 20. Classification of Malignant Lymphomas: State of the Art; S.A. Pileri, E. Sabattini. The Pathologic Spectrum of AIDS-Related Non-Hodgkin's Lymphomas; U. Carbone, et al. 22. Genesis and Progression of Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma; M-Q. Du, P.G. Isaacson. 23. De Novo and Secondary AML Cells Differ in Their Kinetic Response to HGF Priming; M.A. Smith, et al. 24. Molecular Diagnosis of Philadelphia-Positive Leukemias; C. Haškovec, J. Polák. 25. Molecular Monitoring of Non-Hodgkin's Lymphomas; A. Slavickova, et al. Part IV: Regulation of Hematopoiesis. 26. Differential Expression of IL-3 and GM-CSF Receptor Common Signal Transducing Subunit (&bgr;C) During Normal Hematopoietic Differentiation; U. Testa, et al. 27.