Molecular Biology of Brain and Endocrine Peptidergic Systems

ISBN-13: 9781468488036 / Angielski / Miękka / 2013 / 321 str.

M. Chretien

Opis

We had the pleasure and the great opportunity to organize a symposium on "Molecular Biology of Brain and Endocrine Peptidergic Systems" under the auspices of the Canadian Biochemical society and the International Foundation for Biochemical Endocrinology. We were indeed very happy to ass ble a series of first rate speakers who delivered excellent papers on a variety of subjects from the synthesis of complicated peptide analogs, to the creation of trangenic mice, site-directed mutagenesis, enzyme characterization and DNA binding sites. One hundred and seventy-five participants attended the 40 conferences while having the opportunity to look at 24 posters presented by senior scientists as well as students. We, of the organizing committee, feel extremely pleased to have received an overwhelming response from such a group of scholars. We wish to express our sincere gratitude to Mrs. Diane Marcil who arranged most aspects of the meeting with efficiency. We also thank the different organizations and companies for their generous grants which made the reunion possible. We hope that the participants have gained scientifically while having a pleasant sojourn in beautiful Montreal. The organizing committee was made up of a group of dedicated people, particularly its secretary, Dr. Philippe Crine. To all speakers and sessions chairpersons, we are indebted for the excellence of their participation.

Spis treści

Genetic Engineering of Polypeptide Hormones (Mutagenesis).- Functional Dissection of a cAMP-Response Element Using Recombinant Mutations.- Structure Activity Relationship and Peptide Drug Design.- Conformational Constraints in the Design of Receptor Selective Peptides: Conformational Analysis and Molecular Dynamics.- Angiotensin II Antagonists with Prolonged Duration of Action, Possible Anti-Hypertensive Drugs.- New Concepts in Peptide Analog Design.- Clinical and Experimental Applications of Polypeptide Hormones.- Neuropeptidergic Pathways as Possible Targets for the Development of New Therapeutic Agents.- Combination Therapy with the Antiandrogen Flutamide and the LHRH Agonist [D-Trp6, des-Gly-NH210]LHRH Ethylamide in Prostate Cancer: Rationale and 5-year Clinical Experience.- Organelle Organization and Intracellular Trafficking.- Proinsulin Conversion Site.- Hormone and Receptor Ligand Interactions.- Regulation of the Adenylate Cyclase Signalling Pathway: Potential Role for the Phosphorylation of the Catalytic Unit by Protein Kinase A and Protein Kinase C.- Role of Glycosylation in Ligand-Receptor Interactions and Signal Transduction Mechanisms.- Post-Translational Processing of Peptide Hormones.- Molecular Structure of Neutral Endopeptidase 24.11 (Enkephalinase).- The Possible Role of Plasma Kallikrein in Pro-Hormone and Pro-Enzyme Processing.- Sequence Analysis of the Carboxypeptidase E Precursor.- Cellular Mechanisms of Peptide Processing: Focus on ?-Amidation.- The Yeast KEX1 Gene Product Acts as a Carboxypeptidase B-Like Protease in Processing Secreted Protein Precursors.- Receptor Localization and in Situ Hybridization.- Regulation of mRNA in Peptidergic Systems: Quantitative and In Situ Studies.- Cellular and Sub-Cellular Localization of Brain Neurotensin Receptors.- Gonadotropins and Novel Gonadal Peptides. Isolation, Structure and Cloning.- Diversity of Novel Proteins of Gonadal Fluids.- Biochemical and Biological Characterization of LH and FSH Expressed by Recombinant DNA Technology.- Regulation of Neuropeptide Gene Expression.- DNA Binding Proteins and Their Roles in Controlling Tissue Specific Gene Expression and the Responses to Second Messengers.- Molecular Biology and Physiology of Aplysia Neuropeptides.