Molecular Biology of B Cells

ISBN-13: 9780323958950 / Angielski / Twarda / 2024 / 622 str.

Spis treści

1. Structure of Ig locus2. V(D)J recombination3. Origin of V(D)J recombination4. Evolution of B cell receptors5. Structure and function of BCR complex6. Fc and complement receptors7. Transcriptional regulation in early B cell development8. Relationship between B cell populations, development, and function of B cell subsets9. Differentiation programs in developing B cells10. BAFF and Lymphotoxin in B cell biology11. Class switch recombination12. Somatic hypermutation13. Molecular Mechanisms of AID14. B cell lymphomas15. Immune deficiencies caused by B cells defects16. Primary and secondary activation of B cells including the germinal center reaction17. B cell memory and plasma cell development and function and memory plasma cells18. Homeostatic and Pathogenic Autoantibodies19. Anti-TNF therapies in autoimmunity20. Therapeutic targeting of B cells and plasma cells with focus on multiple sclerosis and other autoimmune conditions21. Immunoglobulin Repertoire Analysis and Antibody Humanization22. Development and use of mAbs in infectious disease23. Clinical application of Ab in Cancer24. B cell localization and migration dynamics25. Mucosal immunity to bacteria and IgA synthesis26. Gut microbiota and their regulation27. B cell metabolism28. Parallels between Mouse and Human B cells including aging