Molecular Alterations of the Proteins of the Fibrogenic System

ISBN-13: 9786206413608 / Angielski / Miękka / 60 str.

Alejandra Guillermina Miranda Díaz; José Manuel Hermosillo; Andres Garcia Sanchez

Opis

Biliary tract injury (BTI) is a serious accident manifested by repetitive cholangitis that requires treatment with broad-spectrum antibiotics, prolonged surgery, produces significant risk of re-stenosis, re-operation, secondary biliary cirrhosis, portal hypertension and is capable of leading to death of the patient. Biliary obstruction produces complex hepatic changes with bile acid stagnation that favors the deposition of pro-inflammatory and pro-fibrotic extracellular matrix (ECM) molecules. LVB produces inflammation, oxidative stress, over-expression of TLR, altered fibrinolytic system with increased plasma levels of PAI-1 (p=0.02), decreased levels of MMP-3 (p=0.001). Although levels and deposition in liver tissue of MMP-8 and TIMP-1 were found significantly increased in LVB. Conclusion. Imbalance of pro-fibrogenic / fibrinolytic molecules occurs in LVB, which favors ECM deposition. Overexpression of fibrinolytic proteins such as MMP-8 suggests that liver fibrosis could be limited, preventing liver dysfunction in patients.

O autorze

Surgeon General, Master's Degree in Medical Sciences, Surgery Orientation, Doctorate in Pharmacology, Full Research Professor C, Department of Physiology, Centro Universitario de Ciencias de la Salud. Level 11 of the National System of Researchers. Guadalajara, Jalisco, Mexico.