Modern Mechanobiology: Convergence of Biomechanics, Development, and Genomics

ISBN-13: 9789814800587 / Angielski / Twarda / 2021 / 250 str.

Tzung K. Hsiai; Sharon Gerecht; Hanjoong Jo

Opis

Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme focuses on “omic” approaches to mechanosignal transduction underlying tissue development, injury, and repair.

Spis treści

1. Shear Stress, Mechanosensors, and Atherosclerosis   2. Role of Krüppel-Like Factors in Endothelial Cell Function and Shear Stress–Mediated Vasoprotection   3. Aortic Valve Endothelium Mechanobiology   4. Mechanotransduction of Cardiovascular Development and Regeneration   5. Mechanotransduction in Heart Formation: An Avian Model for Regulating Hemodynamics   6. Mechanotransduction in Cardiovascular Development and Regeneration: A Zebrafish Model for Genetic Manipulation   7. Mechanosensitive microRNAs in Health and Disease   8. Mechanotransduction to the Cell Nucleus   9. Computation of Congenital Heart Disease: A Sheep Model   10. Integrating Light-Sheet Imaging and Shear Stress–Mediated Notch Signaling to Elucidate Cardiac Trabeculation for Contractile Function