Modern Hematology: Biology and Clinical Management

ISBN-13: 9781588295576 / Angielski / Twarda / 2007 / 498 str.

Munker, Reinhold

Opis

Reinhold Munker and his distinguished colleagues have updated and expanded Modern Hematology: Biology and Clinical Management, now in its second edition, to reflect the major advances in the understanding, diagnosis, and treatment of blood disorders. Modern Hematology: Biology and Clinical Management, Second Edition describes the latest clinical and scientific developments, including molecular studies used to diagnose a variety of hematological disorders and guide their treatment. Targeted and molecular therapies are discussed in detail, including kinase inhibitors in myeloproliferative disorders and humanized monoclonal antibodies. The use of peripheral blood and umbilical cord blood stem cells for transplantation is described, as well as the rationale and indications for non-myeloablative transplantation, emphasizing the preferability of immunotherapy over cytotoxic chemotherapy. Modern Hematology: Biology and Clinical Management, Second Edition brings together facts, concepts, and protocols important for the practice of hematology. In 23 chapters, all major blood diseases are covered, as well as rare diseases that are of scientific interest. The first two chapters introduce the reader to the scientific basis of blood disorders. As in the previous edition, each chapter is illustrated by tables, figures, and a selection of color plates. Experts in pediatric hematology, myeloma, blood transfusion, hemoglobinopathies, pharmacology, and infectious diseases have expanded the scope of Modern Hematology. Comprehensive and informative, Modern Hematology: Biology and Clinical Management, Second Edition is an invaluable resource for medical students, hematology trainees, residents, nurses, nurse practitioners, and physicians in other specialties treating patients with benign and malignant blood disorders.

Recenzje

From the reviews of the second edition:

"This book works as a stand-alone text for its intended purpose of providing a practical approach for diagnosis and management. ... Modern Hematology ... is well-designed to accompany structured lectures, practical laboratories, and demonstrations for hematology courses for medical students, medical technologists, and others in related fields. This textbook does the job well. It also is well suited to serve as a basic reference and a means of identifying where to obtain more comprehensive or specialized information." (James R. Egner, Journal of the American Medical Association, December, 2007)

Spis treści

Contents Foreword Preface 1. Basic Biology of Hemopoiesis Reinhold Munker 2. Molecular Biology and Cytokines Reinhold Munker and Amanda Sun 3. Supportive Care in Hematology John Hiemenz and Reinhold Munker 4. Transplantation of Stem Cells from Bone Marrow, Blood and the Umbilical Cord Ronald Paquette and Reinhold Munker 5. Anemias: General Considerations, Microcytic, and Megaloblastic Anemias Reinhold Munker 6. Hemolytic Anemias Reinhold Munker, Ali Mansouri, Snehalata C. Gupte, and Vishwas Sakhalkar 7. Leukocytosis, Leukopenia, and Other Changes of the Myeloid Series Reinhold Munker 8. The Myeloproliferative Syndromes Ronald Paquette, Erhard Hiller, and Reinhold Munker 9. Acute Myelogenous Leukemias Reinhold Munker 10. Acute Lymphoblastic Leukemias Reinhold Munker and Vishwas Sakhalkar 11. Myelodysplastic Syndromes Ronald Paquette and Reinhold Munker 12. Aplastic Anemias Ronald Paquette and Reinhold Munker 13. Lymphocytosis, Lymphopenia, Lymphadenopathy, and Splenomegaly Reinhold Munker 14. Hodgkin's Lymphoma Erhard Hiller and Reinhold Munker 15. The Non-Hodgkin Lymphomas Reinhold Munker, Jay Marion, Gang Ye, and Martin H. Dreyling 16. Multiple Myeloma and Related Paraproteinemias Jonathan Glass and Reinhold Munker 17. Congenital and Acquired Immunodeficiencies Vishwas Sakhalkar and Reinhold Munker 18. Infections Relevant to Hematology Reinhold Munker 19. Basic Principles of Hemostasis Erhard Hiller 20. Bleeding Disorders Erhard Hiller 21. Thrombophilia, Thromboembolic Disease, and Antithrombotic Therapy Erhard Hiller 22. Transfusion Medicine and Immunohematology Grace Tenorio, Snehalata C. Gupte, and Reinhold Munker 23. Storage Disorders in Hematology Reinhold Munker Appendices 1) Glossary of Cytostatic Drugs and Targeted Therapies p 2) CD Nomenclature for Human Leukocyte Antigens p 3) Normal Laboratory Values p 4) Program Requirements for Fellowship Education in Hematology p 5) Databases in Hematology p

O autorze

Now in its second edition, Modern Hematology: Biology and Clinical Management reflects the major advances in the understanding, diagnosis, and treatment of blood disorders. It describes the latest clinical and scientific developments as well as details targeted and molecular therapies. The book brings together facts, concepts, and protocols important for the practice of hematology. In 23 chapters, all major blood diseases are covered, as well as rare diseases that are of scientific interest. As in the previous edition, each chapter is illustrated by tables, figures, and a selection of color plates. Comprehensive and informative this book is an invaluable resource for medical students, hematology trainees, residents, nurses, nurse practitioners, and physicians in other specialties treating patients with benign and malignant blood disorders.

Blurb

Over the past few decades the powerful methods of statistical physics and Euclidean quantum field theory have moved closer together, with common tools based on the use of path integrals. The interpretation of Euclidean field theories as particular systems of statistical physics has opened up new avenues for understanding strongly coupled quantum systems or quantum field theories at zero or finite temperatures.  
 
Accordingly, the first chapters of this book contain a self-contained introduction to path integrals in Euclidean quantum mechanics and statistical mechanics. The resulting high-dimensional integrals can be estimated with the help of Monte Carlo simulations based on Markov processes. The most commonly used algorithms are presented in detail so as to prepare the reader for the use of high-performance computers as an “experimental” tool for this burgeoning field of theoretical physics.
 
Several chapters are then devoted to an introduction to simple lattice field theories and a variety of spin systems with discrete and continuous spins, where the ubiquitous Ising model serves as an ideal guide for introducing the fascinating area of phase transitions.  As an alternative to the lattice formulation of quantum field theories, variants of the flexible renormalization group methods are discussed in detail.  Since, according to our present-day knowledge, all fundamental interactions in nature are described by gauge theories, the remaining chapters of the book deal with gauge theories without and with matter.
 
This text is based on course-tested notes for graduate students and, as such, its style is essentially pedagogical, requiring only some basics of mathematics, statistical physics, and quantum field theory. Yet it also contains some more sophisticated concepts which may be useful to active researchers in the field.  Each chapter ends with a number of problems – guiding the reader to a deeper understanding of some of the material presented in the main text – and, in most cases, also features some listings of short, useful computer programs.