Modern Aspects of Protein Adsorption on Biomaterials

ISBN-13: 9789401056694 / Angielski / Miękka / 2012 / 262 str.

E. Missirlis; W. Lemm

Opis

The present book relates to the scientific records of a workshop held in Patras, Greece, in June 1989, under the auspices and with financial support of the European Economic Communities (Concerted Action EUROBIOMAT - Hemocompatibility - of the Medical Research Programme, Project: 11.1.212). This concerted action promotes the collaboration on science and technology on the particular field of hemocompatible biomaterials: exchange of experts, scholarships and scientific workshops within the EC-member countries and COST countries such as Sweden, Finland, Turkey, Switzerland. The first part of this monography refers to the oral presentations of the par- ticipants. The second part gives the book its unique character: the scientific discussion on updated aspects of protein adsorption of synthetic polymers in contact with blood. This second part is subdivided into nine chapters where specific topics were discussed freely, open-minded and even controversially. This book intends to elucidate recurrent questions concerning the initial event when blood contacts artificial surfaces. Young investigators will consider this book to be appropriate to get familiar with the scientific background and the most relevant techniques and methods.

Spis treści

one: Methods and Techniques to Study the blood Proteins — Artificial Surfaces Interactions.- 1. Can protein adsorption studies using radioisotopic techniques be useful for the development of hemocompatible materials?.- 2. Competitive adsorption of proteins on polymer films: In situ measurements.- 3. Protein adsorption and the interaction of human endothelial cells with polymer surfaces.- 4. Protein adsorption in relation to platelet adhesion and contact activation.- 5. Studies of protein adsorption relevant to blood compatible materials.- 6. Methods to study blood-surface interactions.- 7. Protein adsorption at polymer-liquid interfaces using series of polymers with varying hydrophilicity, charge and chain mobility.- 8. Cooperative protein adsorption on surfaces with controlled alkyl-residue lattices.- 9. Protein adsorption tests for polymer surfaces.- 10. Advantages and problems using FT-IR spectroscopy to study blood- surface interactions by monitoring the protein adsorption process.- 11. Biocompatibility research at Humboldt University.- two: Discussion Chapters.- 12. Protein characterization.- 13. Labelling and protein identification techniques.- 14. Problems of protein adsorption studies — Lyman hypothesis.- 15. Polymer surface properties.- 16. In vitro, in vivo or ex vivo studies.- 17. Kinetics of protein adsorption.- 18. The Vroman effect.- 19. Protein adsorption and thrombus formation.- 20. Concluding remarks.- Authors’ index.