Modelling of an Implantable Device for Localized Hyperthermia

ISBN-13: 9783659366161 / Angielski / Miękka / 2013 / 76 str.

Jonas Bugase;Wole Soboyejo

Opis

A mathematical framework on relaxation losses of heating of magnetite nanoparticles synthesized with Polydimethylsiloxane (PDMS) gel encasement is presented. Numerical solution of the mathematical model showed explicit dependence of the temperature rise of the device on frequency and amplitude of the external applied field, relaxation time and volume fraction of the nanoparticles. Hyperthermia therapeutic temperature of 41 - 46oC can be achieved with an external field of frequency and amplitude in the ranges 2.16 - 2.19 kHz and 9.77 - 9.89 kA/m respectively. Also, viscosity and volume fraction of the nanoparticles lies in the ranges 1.1 - 1.2 mPa.s and 0.12 - 0.14 respectively. Simulation of the heat diffusion profile of the implant and its surrounding tumor was done using Abaqus/CAE 6.9, a finite element simulation package. In 2D, the results showed that for maximum generated temperatures of 52oC and 55oC, the tumor temperature was maintained within the therapeutic range for more than thirty minutes in conformity with predicted theory. However, the tumor temperature falls below the therapeutic range for generated temperature of 45oC.

O autorze

Bugase Jonas was born on May 9th, 1985. He graduated with a BSc in Applied Physics from University for Development Studies, Tamale. Jonas attained an MSc in Theoretical Physics at the African University of Science and Technology, Abuja and currently a lecturer at his BSc alma mater. His research interest is in superconductivity and magnetism.