Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities

ISBN-13: 9780443152603 / Angielski

John J. Lemasters

Opis

Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention. This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.

Spis treści

Part I - Machinery and Mechanisms 1. Overview on mitophagy, mito-dynamics, and mito-biogenesis 2. Parkin-dependent mitophagy machinery 3. Ubiquitin-dependent mitophagy 4. Ub-independent mitophagy 5. MDVs and other piecemeal clearance mechanisms 6. Mitochondrial proteostasis mechanisms 7. MitoUPR 8. Mitochondria in extracellular vesicles 9. Linking mitophagy and mito-biogenesis 10. Mitophagy through the human lifespan, Disease, and Conditions Part II - Overview of Mitophagy through the human lifespan 11. Mitophagy in erythroid development 12. Mitophagy in muscle differentiation 13. Mitophagy in cancer 14. Extracellular matrix signals to mitochondria 15. Mitophagy in inflammation 16. Mitophagy in cardiac tissue, pressure overload or ischemic injury 17. Mitophagy in brain and neurodegenerative disease 18. Mitophagy in aging 19. Nitophagy in fatty liver disease Part III - Therapeutic Interventions Targeting Mitophagy 20. Autophagy/mitophagy inducers 21. Mitophagy inducers 22. Bnip3 targeting 23. Enhancing autophagy/mitophagy with TFEB 24. Cardioprotection through mitophagy 25. Preventing neurodegeneration through mitophagy 26. Fasting, mitophagy, and aging 27. Future developments