Mitochondrial Genetics and Cancer

ISBN-13: 9783642114151 / Angielski / Twarda / 2010 / 356 str.

Gabriel D. Dakubo

Opis

This pioneering book is a unique compilation of mitochondrial genome alterations in cancer. It focuses on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways.

Spis treści

PART 1: GENERAL OVERVIEW OF MITOCHONDRIAL GENETICS AND FUNCTIONS 1. Basic Mitochondrial Genetics, Bioenergetics and Biogenesis 2. The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells 3. Mitochondrial Control of Apoptosis and Cancer 4. Mitochondrial-to-Nuclear Communications in Cancer PART 2: MITOCHONDRIAL GENETIC ALTERATIONS IN CANCER 5. Types of Mitochondrial Genetic Alterations in Cancer 6. Mitochondrial Genetic Alterations in Cancer I: Skin, Head and Neck, 7. Mitochondrial Genetic Alterations in Cancer II: Renal, Urinary Bladder, Prostate, Ovarian, Endometrial, Cervical, Nervous System, Hematologic, and Connective Tissue Cancers 8. Mitochondrial Genome Rearrangements and Copy Number Changes in Cancer 9. Functional Importance of Mitochondrial Genetic Alterations in Cancer 10. The Role of Mitochondrial Reactive Oxygen Species in Cancer PART 3: CLINICAL APPLICATIONS OF MITOCHONDRIAL GENOME CHANGES IN CANCER 11. Mitochondrial DNA Measurement in Exfoliated Cells for Cancer Detection and Monitoring – the Copy Number Advantage 12. Early Cancer Detection and Monitoring Using Changes in the Mitochondrial Genome as Biosensors 13. Analysis of Mitochondrial Genome Alterations in Cancer 14. “Mitocans”: Agents Targeting Mitochondrial to Kill Cancer Cells

O autorze

Gabriel D. Dakubo is the founder of Mito-Onc Consultancy, a pioneer consulting firm that provides evidence-based advice on discovery, validation and regulatory submission of cancer biomarkers based on mitochondrial genomic alterations.

Blurb

The pivotal role of mitochondrial functions in carcinogenesis is quite well established. However, the critical role of mitochondrial genome alterations to cancer development is muted in traditional textbooks. Recent scientific efforts have provided unequivocal evidence for mitochondrial genome mutations and content changes in cancer development, progression, and therapy. This pioneering book is a unique compilation of mitochondrial genome alterations in cancer. While primarily focused on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways, attention is also given to the metabolic transformations of the cancer cell, as well as the established altered cell death processes that underlie cancer evolution and treatment resistance.