Midkine: From Embryogenesis to Pathogenesis and Therapy

ISBN-13: 9789400742338 / Angielski / Twarda / 2012 / 338 str.

Mine Erg Ven; Takashi Muramatsu; Ayhan Bilir

Opis

Carl Edward Sagan's (1934-1996) one of the famous quotation was "Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people." From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named "Midkine" This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent.

Spis treści

PART I:  GENERAL ASPECTS OF MIDKINE

CHAPTER  1         General information on midkine

CHAPTER  2         The role of midkine in neural development and patterning

CHAPTER  3         Midkine-  A player in innate immunity

CHAPTER  4         Midkine/p63 axis in regulation of epithelial-mesenchymal transition

CHAPTER  5        Immunochemical methods for the detection of midkine in samples of human origin

CHAPTER  6        Circulating midkine in malignant, inflammatory, and infectious diseases: a systematic review

 

PART II: MIDKINE AND INFLAMMATION

CHAPTER  7         Midkine in inflammation and inflammatory diseases

CHAPTER  8        Rheumatoid arthritis and midkine

 

PART III: MIDKINE AND THE CARDIOVASCULAR SYSTEM

CHAPTER  9         Midkine and heart failure

CHAPTER  10       Vascular restenosis and midkine

CHAPTER  11       The potential of MK through the renin-angiotensin system

 

PART IV: MIDKINE AND THE NERVOUS SYSTEM

CHAPTER  12       Midkine and Multiple sclerosis

CHAPTER  13       MK gene transfer in brain infarction

CHAPTER  14       Midkine in psychiatric and neurodegenerative diseases  

 

PART V: MIDKINE  AND THE UROGENITAL SYSTEM, REPRODUCTION AND AGING

CHAPTER  15       Role of midkine in nephrogenesis and kidney Disease

 CHAPTER  16      Midkine, a factor promoting cytoplasmic maturation of oocytes

CHAPTER 17        Endometriosis may be promoted by midkine: possible involvement of ovarian follicles

CHAPTER 18        Stem cells and midkine

CHAPTER 19        Midkine in skeletal physiology

PART VI MIDKINE AND CANCER

CHAPTER 20        Midkine  and chemotherapy resistance in cancers

CHAPTER 21       A  gene medicine with the midkine transcriptional regulation as new cancer therapeutics

CHAPTER 22       Midkine  as a tumor shared antigen

CHAPTER 23       Midkine in prostate cancer

CHAPTER 24       Midkine is a potential therapeutic target of hepatocellular carcinoma

CHAPTER 25       Midkine in glioblastoma with the modulator role switching autophagy to cell death or cell survival

CHAPTER 26      Colon cancer and midkine

CHAPTER 27       Osteosarcoma and midkine

Index.

Blurb

Carl Edward Sagan’s (1934-1996) one of the famous quatation was “Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.“ From past to date, well-known molecules, enzymes, proteins, lipids and carbonhydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgetten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named “Midkine” This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent.