Micrornas: Key Regulators of Oncogenesis

ISBN-13: 9783319037240 / Angielski / Twarda / 2014 / 433 str.

Sadegh Babashah

Opis

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.

Spis treści

Preface 

Part I MicroRNAs: biology and implications in cancer

1 MicroRNAs and cancer: an overview
Sadegh Babashah

2 Epigenetics and microRNA in cancer
Jiazeng Xia, Xiaoqiang Guo, Kaiyuan Deng 

3 MicroRNA, diet and cancer chemoprevention
Sharanjot Saini, Rajvir Dahiya

4 MicroRNAs and energy metabolism in cancer cells
Linchong Sun, Xiaoping He, Yang Cao, Ping Gao, Huafeng Zhang

5 MicroRNAs and solid tumors
Gianpiero Di Leva, Michela Garofalo 

6 MicroRNAs and blood cancers
Charles H Lawrie 

7 MicroRNAs and oncogenic human viruses
Muriel Thirion, Teru Kanda, Yoshiki Murakami, Takahiro Ochiya, Hisashi Iizasa

8 MicroRNAs linking cancer and inflammation: focus on liver cancer
Angélique Gougelet and Sabine Colnot 

9 MicroRNAs and regulatory pathways in tumorigenesis
Jun Wei, Yong Li, Xiaoming Liu, William C. Cho

10 MicroRNA-modulated apoptotic and autophagic signaling networks in cancer
Bo Liu, Yu-quan Wei 

11 MicroRNAs and cancer drug resistance and drug sensitivity
Hugo Seca, Raquel T. Lima, M. Helena Vasconcelos 

12 The biological roles of microRNAs in cancer stem cells
Bin Bao, Asfar S. Azmi, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Shadan Ali, and Fazlul H. Sarkar 

Part II MicroRNAs and their clinical implications

13 MicroRNAs and clinical implications in cancer
Jürgen Wittmann 

14 MicroRNA expression profiling and its clinical impact in breast cancer
Manuela Ferracin, Laura Lupini

15 MicroRNAs and their clinical impact on resistance to anticancer treatment
Kirsten Lindner, Joerg Haier, Richard Hummel 

16 Nanocarriers and microRNA-based scenarios for cancer therapy
Babak Bakhshinejad, Mohammad Amin Javidi, Sahar Babashah, Sadegh Babashah 

17 Challenges and strategies for pulmonary delivery of microRNA-based therapeutics
Yu Fujita, Kazuyoshi Kuwano ,Takahiro Ochiya 

Abbreviations

Index

Blurb

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs play a momentous role in oncogenesis via regulating cell proliferation and apoptosis as oncogenes or tumour suppressors. Expression signatures of miRNAs offer exciting opportunities for crafting cutting edge strategies in the diagnosis, prognosis, and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in the tortuous route of oncogenesis, the promise represented by using these small RNAs as therapeutic targets presents new perspectives to the landscape of cancer therapy by either inhibiting or augmenting their activity. This book devotes efforts to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of miRNAs found to be associated with cancer pathogenesis and possible mechanisms underlying the substantial roles played by miRNAs in cancer development and progression. Also, it intends to pave the way for readers to gain novel insights into using miRNAs as cancer biomarkers and therapeutic platforms.