Microrna: From Bench to Bedside

ISBN-13: 9780323897747 / Angielski / Miękka / 2022

Junjie Xiao

Spis treści

Part I: Overview
1. An overview of microRNAs

Part II: Methodology and Bioinformatics
2. MicroRNA isolation
3. Detection of microRNA
4. MicroRNA Interference
5. Target prediction and validation of microRNA
6. Online databases for microRNA Research

Part III: Biogenesis and Maturation
7. Biogenesis of microRNAs
8. Molecular basis for microRNA processing
9. Maturation of microRNAs

Part IV: Molecular Mechanisms and gene regulation
10. Function microRNA in cytoplasm
11. Mechanisms of miRNA Nuclear Localization
12. MiRNA-Mediated Transcriptional Regulation
13. Epigenetic Regulation and microRNA Expression
14. RNA m6A modification and microRNAs

Part V: MicroRNA as biomarkers
15. Detection Methodologies for microRNA biomarker profiling
16. Circulating microRNAs
17. MicroRNA Profiling of Exosomes
18. MicroRNAs and biomarkers

Part VI: MicroRNAs and human diseases
19. MicroRNAs and Cancers
20. MicroRNAs and the Immune System
21. MicroRNAs in Cardiovascular Diseases
22. MicroRNAs in aging and age-related Diseases
23. MicroRNAs in Neurological Diseases
24. MicroRNAs in Muscle Atrophy
25. MicroRNAs in Respiratory Diseases
26. MicroRNAs in Liver Diseases

Part VII: MicroRNA Based Therapeutics
27. Overview of MicroRNA Based Therapeutics
28. MicroRNA Based Therapeutic Strategies for Cancer
29. MicroRNA Targeted Therapy in Cardiovascular disease
30. MicroRNA Targeted Therapy in Hepatitis
31. MicroRNA Based Therapeutic Strategies for Diabetes
32. Clinical studies involving microRNAs

Part VIII: Concluding Perspectives
33. Prospective advances in microRNAs investigation