Micronutrients and Brain Health

ISBN-13: 9781420073515 / Angielski / Twarda / 2009 / 460 str.

Lester Packer; Helmut Sies; Manfred Eggersdorfer

Opis

Micronutrients and Brain Health addresses cutting-edge research related to processes of oxidative stress that affect brain function, an area of increasing significance for those concerned and involved with public health and translational medicine. Edited by four leading micronutrient researchers, the book brings together the investigative work of more than 70 leading researchers from across the world. Chapters identify brain-specific micronutrients that support function as well as the molecular mechanisms underlying their neuroprotectant activity. These explore age-related metabolic pathways, mitochondrial nutrients, neurodegeneration and micronutrients, cell signaling, and neuronal functions. General chapters are included on brain structure, function, and metabolism, while several other chapters are devoted to the role of specific micronutrients. The book explores how brain micronutrients are found to be both metabolic and redox regulators, thereby establishing a cross-talk between the major pathways involved in modulation of cell signaling and gene expression. Specific areas of research covered include:

• Uses of nutritional interventions to target age-related neuronal and behavioral deficits
• Effects of various micronutrients on Alzheimer s disease, including lipoic acid, green tea, and Ginkgo biloba extracts
• Nutrients specific to essential mitochondrial functions
• Cognitive and behavioral consequences of iron deficiency with specific emphasis on women of reproductive age
• Omega-3 fatty acids and their relation to brain function in the elderly
• Challenges inherent in the development of neuroprotective-neurorescue drugs

This book belongs to the groundbreaking CRC Press Series on Oxidative Stress and Disease. The series now includes more than two dozen volumes that address increasing evidence regarding the multiple ways that oxidative stress initiates and accelerates disease mechanisms. Most importantly, this book, like the series, offers invaluable information regarding nutritional and lifestyle choices, and pharmaceutical interventions that can be employed to prevent, control, and even ameliorate disease processes attributed to oxidative stress. "

Spis treści

Neuroprotection after Cardiac Arrest by Avoiding Acute Hyperoxia and by Antioxidant Genomic Postconditioning. The Neuroprotective Role of Micronutrients in Parkinson’s. Food Antioxidants and Alzheimer’s Disease. Micronutrient Antioxidants, Cognition, and Neuropathology: A Longitudinal Study in the Canine Model of Human Aging. Excitatory Amino Acids, S-nitrosylation, and Protein Misfolding in Neurodegenerative Disease: Protection by Memantine and NitroMemantine at NMDA-Gated Channels. Cognitive and Behavioral Consequences of Iron Deficiency in Women of Reproductive Age. Micronutrient Needs of the Developing Brain: Priorities and Assessment. Therapeutics of Alzheimer’s Disease Based on Metal Bioavailability. Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease. Zinc and the Cytoskeleton in Neuronal Signaling. Tocotrienol Neuroprotection: The Most Potent Biological Function of All Natural Forms of Vitamin E. Fruits, Nuts, and Brain Aging: Nutritional Interventions Targeting Age-Related Neuronal and Behavioral Deficits. Modulation of Multiple Pathways Involved in the Maintenance of Neuronal Function. Dietary Flavonoids as Neuroprotective Agents. Actions of Bioactive Phytochemicals in Cell Function and Alzheimer’s Disease Pathology. Does Ginkgo biloba Extract Exert an Effect on Alzheimer’s Disease Progression. Green Tea Polyphenols Protect Neurons against Alzheimer’s Disease and Parkinson’s Disease. Transport of Flavonoids into the Brain. Prevention and Treatment of Neurodegenerative Diseases by Spice-Derived Phytochemicals. Neurohormetic Properties of the Phytochemical Resveratrol. Sirtuin and Resveratrol. Acetyl-l-Carnitine and Ferulic Acid Action in Aging and Neurodegenerative Diseases. Evidence Required for Causal Inferences about Effects of Micronutrient Deficiencies during Development on Brain Health: DHA, Choline, Iron, and Vitamin D. Omega-3 Fatty Acids and Brain Function in Older People. Iron and Monoamine Oxidase in Brain Function and Dysfunction: Development of Neuroprotective-Neurorescue Drugs. Antioxidative Defense of Brain Microglial Cells. Branched-Chain Amino Acids and Brain Metabolism.

O autorze

Lester Packer, Helmut Sies, Manfred Eggersdorfer, Enrique Cadenas