Microarray Bioinformatics

ISBN-13: 9781493994441 / Angielski / Miękka / 2020 / 299 str.

Veronica Bolon-Canedo;Amparo Alonso-Betanzos

Opis

This book provides a comprehensive, interdisciplinary collection of the main, up-to-date methods, tools, and techniques for microarray data analysis, covering the necessary steps for the acquisition of the data, its preprocessing, and its posterior analysis. Featuring perspectives from biology, computer science, and statistics, the volume explores machine learning methods such as clustering, feature selection, classification, data normalization, and missing value imputation, as well as the statistical analysis of the data and the most popular computer tools to analyze microarray data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that will aid researchers in getting successful results. Cutting-edge and authoritative, Microarray Bioinformatics serves as an ideal guide for researchers and graduate students in bioinformatics, with basic knowledge in biology and computer science, and with a view to work with microarray datasets.

Spis treści

1. Introduction to Bioinformatics
2. Introduction to DNA microarrays
3. Data Warehousing
4. Microarray Annotation
A review of microarray datasets: where to find them and specific characteristics
5. Statistical analysis of microarray data
6. Feature selection applied to microarray data
7. Cluster analysis of microarray data
8. Classification of microarray data
9. Microarray data normalization and transformation
10. HPC tools to deal with microarray data
11. Sequence alignment with microarray data
12. Experimental design of microarrays
13. ROC curves for microarrays
14. Image processing and microarrays
15. Challenges and future trends