MicroRNAs in Cancer Translational Research

ISBN-13: 9789400702974 / Angielski / Twarda / 2011 / 557 str.

William C. S. Cho

Opis

MicroRNA (miRNA) is a cutting-edge topic in the scientific and medical fields. This is a timely and specialized book focusing on the current understanding of miRNAs and the potential for their application in cancer diagnosis, prognosis, and therapeutic targets. It also provides discussion of the lessons learned from translational miRNA studies and exploration of the next steps required to advance this field.The unique book comprises 22 in-depth chapters by gathering unparalleled topics of interest in miRNAs by international team of world-renowned experts in the field. The first fifteen chapters provide comprehensive and expert perspectives on the most common cancers from bench to bedside applications, there is no current book structured in this cancer-oriented way. The next seven chapters providing thorough overviews of miRNAs and cancer stem cells; miRNAs in cancer invasion and metastasis; miRNAs in predicting radiotherapy and chemotherapy response; as well as expounding the role of miRNA in anti-cancer drug resistance and as blood-based cancer biomarkers. Furthermore, this book explicates the interplay of miRNAs in cancer metabolism and an update on the pioneering RNAi-based treatment approaches is also presented.This specialized book will contribute great to the scientific and medical community by providing the up-to-date discoveries of miRNAs and their important roles in cancer translational research.

Recenzje

From the reviews:

"The editor William C. S. Cho provides a comprehensive coverage and a succinct overview of the state-of-the-art knowledge on miRNA research ... . a rich and thorough compendium uniting all relevant aspects of miRNA-stimulated translational cancer research. It covers ... a proper spectrum of relevant topics and thus can be recommended for a broad scientific and medical readership. MCTR is a precious book for all types of readers: cancer researchers, oncologists, pathologists, biologists, clinical chemists, pharmacologists, and even bioinformaticians." (Dominic Rose, Frontiers in Genetics, Vol. 3 (42), March, 2012)

Spis treści

1.- MicroRNAs in Cancer (An Overview).- 2. The Role of MicroRNAs in Lung Cancer Development, Progression, and Metastasis.- 3. MicroRNAs in Breast Cancer.- 4. MicroRNAs in Colorectal Cancer.- 5. MicroRNAs in Gastric Cancer.- 6. MicroRNAs in Prostate Cancer: A Possible Role as Novel Biomarkers and Therapeutic Targets?- 7. MicroRNAs in Hepatocellular Carcinoma.- 8. MicroRNAs in Cervical Carcinoma.- 9. MicroRNAs in Esophageal Cancer.- 10. MicroRNAs in Bladder Cancer.- 11. MicroRNAs in Lymphoma.- 12. MicroRNAs in Leukemia.- 13. MicroRNAs in Pancreatic Cancer: Potential Interests as Biomarkers and Therapeutic Tools.- 14. MicroRNAs in Epithelial Ovarian Cancer.- 15. MicroRNAs in Brain Tumors.- 16. MicroRNAs and Cancer Stem Cells.- 17. MicroRNAs in Cancer Invasion and Metastasis.- 18. MicroRNAs in Predicting Radiotherapy and Chemotherapy Response.- 19. Role of MicroRNAs in Anti-cancer Drug Resistance.- 20. MicroRNAs and Cancer Metabolism.- 21. MicroRNAs as Blood-based Biomarkers of Cancer.- 22. RNAi-based Approaches to the Treatment of Brain Tumors.