Mg2+ and Excitable Membranes

ISBN-13: 9783642756382 / Angielski / Miękka / 2011 / 150 str.

Piergiorgio Strata; Emilio Carbone

Opis

This volume presents the most recent research findings on the key role played by Mg2+ in the regulation of ion channels in excitable tissue. Contributions describe the multiple actions exerted by Mg2+ on the different types on ion channels controlling nerve and cardiac cell activity. Recent developments in the detection of single ion channel activity provide important insights into the mechanisms of action of Mg2+ at the channel level.

Spis treści

Use of Ion Selective Microelectrodes to Measure Intracellular Free Mg2+.- Voltage-Gated Ionic Channels: Diversity and Modulation by Mg2+.- ATP-Dependent K+ Channels of Excitable Membranes.- Voltage-Dependent Blockage of Cardiac Inwardly Rectifying K+ Channels by Internal Mg2+.- Regulation of the Voltage-Gated Ca2+ Current by Intracellular Free Mg2+ Studied by Internal Perfusion of Single Cardiac Myocytes.- Blockage of Neuronal Low-Threshold Ca2+ Channels by Extracellular Mg2+.- Dual Blockage by Mg2+ of the N-Methyl-D-Aspartate-Activated Channel.- Excess Mg2+ and Central Nervous System Metabolism.- Mg2+ in Neurotrauma: Its Role and Therapeutic Implications.