Methods of Cancer Diagnosis, Therapy, and Prognosis: General Overviews, Head and Neck Cancer and Thyroid Cancer

ISBN-13: 9789400731394 / Angielski / Miękka / 2012 / 476 str.

M. A. Hayat

Opis

There are more than 100 types of cancers In Part II, head and neck cancer is d- affecting all parts of the human body. cussed. The global number of annual new More than 11 million people are diagnosed cases of this malignancy is 500,000. These with cancer every year, and it is estimated malignancies include oral squamous cell that there will be 16 million new cases by carcinoma, salivary gland tumors, tons- the year 2020. In 2005, 7. 6 million peo- lar cancer, tongue cancer, nasopharyngeal ple died of cancer, that is, 13% of the 58 carcinoma, and retinoblastoma, which are million deaths worldwide. It is estimated detailed. In Part III, diagnosis, therapy, and that 9 million people will die from can- prognosis of thyroid carcinoma are d- cer worldwide in 2015 and 11. 4 million cussed. The global number of new cases of will die in 2030. More than 70% of all thyroid cancer is 141,000, and the number cancer deaths occur in low and middle of worldwide thyroid mortalities is 35,375. income countries. These statistics underlie The number of new cases of this cancer in the fact that cancer is the deadliest of all the United States is 33,550. Molecular human diseases. The enormity of the glo- genetics of thyroid cancer, gene expr- bal healthcare costs as a result of cancer sion markers for diagnosis, papillary t- cannot be overemphasized.

Spis treści

PART I. GENERAL METHODS AND OVERVIEWS Diagnosis 1. ROLE OF RNA INTERFERENCE IN UNDERSTANDING THE MOLECULAR BASIS OF CANCER; Jeffrey P. MacKeigan and Alex Gaither MECHANISM OF RNA INTERFERENCE RNA INTERFERENCE AS A CELL BASED SCREENING TOOL RNA INTERFERENCE TO UNDERSTAND COMPOUND MECHANISM OF ACTION COMPOUND SENSITIZATION, COMBINATION STRATEGIES AND SYNTHETIC LETHAL RNA INTERFERENCE SCREENS PROBLEMS ASSOCIATED WITH RNA INTERFERENCE BASED APPROACHES REFERENCES 2. CANCER BIOMARKERS (AN OVERVIEW); William C.S. Cho INTRODUCTION EMERGING TECHNOLOGIES FOR CANCER BIOMARKER DISCOVERY DNA Microarray Serial Analysis of Gene Expression MicroRNA Microarray Two Dimensional Polyacrylamide Gel Electrophoresis Free Flow Electrophoresis Capillary Electrophoresis Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Liquid Chromatography Coupled with Tandem Mass Spectrometry Linear Ion Trap Quadrupole-Orbitrap Imaging Mass Spectrometry Isotope-Coded Affinity Tags Multiple Reaction Monitoring Absolute Quantification of Proteins Protein Microarray Tissue Array Bioinformatics CURRENTLY USED CANCER BIOMARKERS BIOMARKERS FOR THE DIAGNOSIS OF CANCERS Genomic-based Biomarkers in Cancer Transcriptomic-based Biomarkers in Cancer Proteomic-based Biomarkers in Cancer BIOMARKERS FOR THE TREATMENT AND PROGRESSION OF CANCERS Genomic-based Biomarkers in Cancer Transcriptomic-based Biomarkers in Cancer Proteomic-based Biomarkers in Cancer BIOMARKERS FOR THE PROGNOSIS OF CANCERS Genomic-based Biomarkers in Cancer Transcriptomic-based Biomarkers in Cancer Proteomic-based Biomarkers in Cancer CHALLENGES AND PERSPECTIVES REFERENCES 3. TUMOR ANGIOGENESIS IN CANCERS: EXPRESSION OF CD105 MARKER; Osamu Tokunaga, Rahmawati Minhajat, and Daisuke Mori INTRODUCTION MORPHOLOGICAL FEATURES OF TUMOR ANGIOGENESIS DETECTION OF THE ENDOTHELIUM IMMUNOHISTOLOGY Antigenecity Retrieval Immunohistology SIMULTANEOUS MASS AND COMPARATIVE STUDY: TISSUE ARRAY SPECIFIC MARKERS FOR VASCULAR ENDOTHELIUM IN TUMORS Angiogenesis CD105/ENDOGLIN ENDOTHELIAL MARKER SPECIFIC FOR NEWLY FORMED BLOOD VESSELS CD105 AND VASCULOGENESIS ORGAN SPECIFICITY OF CD105 POSITIVE TUMOR ANGIOGENESIS APPLICATION OF CD105 FOR ANTI-ANGIOGENIC CANCER THERAPY REFERENCES 4. SPINDLE CELL ONCOCYTOMA OF THE ADENOHYPOPHYSIS: INTEGRATED CLINICOPATHOLOGIC DIAGNOSIS BY IMAGING, HISTOLOGY, AND IMMUNOHISTOCHEMISTRY; Istvan Vajtai and Rahel Sahli INTRODUCTION CLINICAL PRESENTATION IMAGING ASPECTS HISTOLOGY AND IMMUNOPHENOTYPE DIFFERENTIAL DIAGNOSIS THERAPEUTIC AND PROGNOSTIC IMPLICATIONS DISCUSSION AND PERSPECTIVES REFERENCES 5. DISSEMINATED CARCINOMA OF UNKNOWN PRIMARY SITE: DETECTION WITH F-FLUORODEOXYGLUCOSE- POSITRON EMISSION TOMOGRAPHY; Pascal Sève and John R. Mackey INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION REFERENCES 6. UNKNOWN LYMPHADENOPATHY: DIAGNOSIS USING AN ENDOSCOPIC ULTRASOUND-GUIDED FINE-NEEDLE ASPIRATION; Ichiro Yasuda INTRODUCTION APPLICATION EQUIPMENT PROCEDURE DIAGNOSTIC YIELD REFERENCES Therapy 7. PRETARGETED RADIOIMMUNOTHERAPY IN CANCER: AN OVERVIEW; Stefano Papi, Chiara Maria Grana, Mirco Bartolomei, Laura Ravasi, Marta Cremonesi, Mahila Ferrari, Luigi Martano, Lucia Garaboldi, Marco Chinol, and Giovanni Paganelli INTRODUCTION THERAPEUTIC RADIOISOTOPES LIMITATIONS OF CLASSICAL

Blurb

The seventh volume of the series, Methods of Cancer Diagnosis, Therapy, and Prognosis, discusses General Methods, Overviews, Head and Neck Cancer, and Thyroid Cancer. As in the other six volumes of the series, these subjects are discussed in detail.

This fully illustrated volume presents overviews in

• Radio-immunotherapy in Cancer
• Multidrug Resistance
• Cancer Biomarkers
• Role of Antibodies in Cancer Treatment
• Classification of Cancer Stage Using Patient’s Immune System
• Cancer Stem Cells

General methods discussed are

• Translating In Vitro Cell Lines Result into Clinical Practice
• Late Relapse of Germ Cell Malignancies
• Role of RNA Interference in Understanding the Molecular Bases of Cancer
• Incorporating Pharmacogenomics into Cancer Therapy
• Tumor Angiogenesis in Cancer
• Spindle Cell Oncocytoma of the Adenohypophysis
• Chemotherapy-Induced Neurotoxicity
• Disseminated Carcinoma of Unknown Primary Site
• Unknown Lymphadenopathy

In part 2 of this volume Head and Neck Squamous Cell Carcinoma, Early Stage Oral Squamous Cell Carcinoma, Salivary Gland Tumors, Retinoblastoma, Tongue Cancer Metastasis, Role of Human Papilloma Virus in Tonsillar Cancer and Nasopharyngeal Carcinoma are discussed.

Part 3 discusses in detail Thyroid Carcinoma, including Papillary Thyroid Carcinoma,Molecular Genetics of the Thyroid, Medullary Thyroid Carcinoma, PET Imaging in Thyroid carcinoma, Thyroid Cancer and Markers for Diagnosis, Metastasized Medullary Thyroid Carcinoma, and Prognostic Factors in Thyroid Carcinoma.

The information presented in this volume should help in the development of novel, more effective therapeutic approaches for the treatment of head and neck cancer and thyroid cancer.

Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.