Metastatic Bone Disease: Fundamental and Clinical Aspects

ISBN-13: 9783540573562 / Angielski / Miękka / 1993 / 186 str.

Ingo J. Diel; Manfred Kaufmann; Gunther Bastert

Opis

Bone metastases often develop from malignant tumours and lead to complications. This study explores the pathophysiology, diagnosis and treatment of metastatic bone disease and discusses how antiosteolytic substances such as biophosphonate can supplement established therapies.

Spis treści

Historical Remarks on Metastasis and Metastatic Bone Disease.- Nature of Metastatic Bone Disease.- Incidence and Distribution of Bone Metastases.- Detection and Characterization of Tumor Cells in Bone Marrow of Patients with Primary Breast Cancer.- Normal Bone Remodeling and Metastatic Bone Disease.- Morphological Findings in Bone Metastasis, Tumorosteopathy and Antiosteolytic Therapy.- Mechanisms of Osteolytic Bone Destruction.- Diagnosis of Skeletal Metastases and Assessment of Response to Treatment.- Biochemical Markers of Bone Metabolism in Metastatic Bone Disease.- Palliative Radiotherapy of Bone Metastases.- Systemic Treatment of Bone Metastases: Review of Literature and Retrospective Analysis of 718 Breast Cancer Patients.- Bisphosphonates: Mechanism of Action and Clinical Use in Hypercalcemia of Malignancy and Tumor-Induced Bone Destruction.- Clodronate Decreases Skeletal Morbidity in Patients with Bone Metastases from Breast Cancer: A Double-Blind Randomized Controlled Trial.

O autorze

Prof. Dr. med. Manfred Kaufmann ist Direktor der Klinik für Gynäkologie und Geburtshilfe der Johann-Wolfgang-Goethe-Universität in Frankfurt am Main sowie Kuratoriumsvorsitzender der neu gegründeten Deutschen Krebsstiftung. Prof. Kaufmann gilt als einer der profiliertesten Brustkrebsforscher.