Mesalamine and antioxidant therapy for treatment of IBD

ISBN-13: 9786204736549 / Angielski / Miękka / 100 str.

Jagdish Kakadiya; Rajshari Patel

Opis

To evaluate effect of Combination of Mesalazine and Ellagic Acid on experimentally induced inflammatory bowel disease in Mice and evaluate biological parameters like demographic parameters, Bio Markers, Serologic marker, inflammatory markers Prepare an optimized concentration of DSS in sterile water by weighing DSS powder and mixing until a clear solution is achieved. Administered the 2-3% of DSS orally for 7 days. Measure body weight daily and Collect faeces by placing single mice in an empty cage without bedding material for 15 to 30 min. With sterile forceps, collect faeces and observe. The result shows that treatment with Ellagic Acid and Mesalazine individually is able to improve the inflammatory conditions by suppressing the various inflammatory mediators. But the combination of this Ellagic Acid and Mesalazine produce more significant effect than the individual one. There combination shows more positive effect on histopathology and biochemical estimations than the individual drug effect. So the combined drug treatment of IBD might stand as positive future treatment aspect for the inflammatory conditions of Bowel Disease.

O autorze

Kakadiya, JagdishDr Jagdish L Kakadiya is an Academician and researcher in the domain of Pharmacy field more than 12 years. He has published more than 35 research and review papers in national & international journals. He is including as Editor board Member, Chief editor in many national and international journals. He has 10 h-index, 10 i10 Index in Google Scholar.