Membrane Transport and Renal Physiology

ISBN-13: 9780387954813 / Angielski / Twarda / 2002 / 404 str.

Harold Erick Layton; Al P. Perkins; H. Layton

Opis

The papers in this volume arose out of the workshop Membrane Transport and Renal Physiology, which was conducted as part of the IMA 1998-1999 program year, Mathematics in Biology. The workshop brought together physiologists, biophysicists, and applied mathematicians who share a common interest in solute and water transport in biological systems, especially in the integrated function of the kidney. Solute and water transport through cells involves fluxes across two cell membranes, usually via specialized proteins that are integral membrane components. By means of mathematical representations, transport fluxes can be related to transmembrane solute concentrations and electrochemical driving forces. At the next level of functional integration, these representations can serve as key components for models of renal transcellular transport. Ultimately, simulations can be developed for transport-dependent aspects of overall renal function. Workshop topics included solute fluxes through ion channels, cotransporters, and metabolically-driven ion pumps; transport across fiber-matrix and capillary membranes; coordinated transport by renal epithelia; the urine concetrating mechanism; and intra-renal hemodynamic control. This volume will be of interest to biological and mathematical scientists who would like a view of recent mathematical efforts to represent membrane transport and its role in renal function.

Spis treści

Ionic energetics in narrow channels * The physical basis of ion channel kinetics * The use of streaming potential measurements to characterize biological ion channels * A kinetic model for secondary active transport * Asymmetry of the AE1 anion exchange system*Epthelial ion transport * Assessing homeostatic properties of epithelial cell models * Limitations in the application of fiber-matrix models to glomerular basement membrane * Transport of macromolecules across the peritoneum * Urinary concentrating mechanism*Urine concentrating mechanism*Transport processes in the microcirculation of the renal medulla * Mathematical models of the mammalian urine concentrating mechanism * Lactate accumulation in the kidney inner medulla * Kidney-specific responses of myogenic autoregulation to inhibition of nitric oxide synthase * TGF gain and effector mechanism * Analysis of generative and dissipative flow-dependent mechanisms in tubuloglomerular feedback * A reduced model for nephron flow dynamics mediated by tubuloglomerular feedback * Dynamic model of nephron-nephron interaction