Melanoma Development: Molecular Biology, Genetics and Clinical Application

ISBN-13: 9783319413174 / Angielski / Twarda / 2017 / 447 str.

Anja K. Bosserhoff

Opis

This book focuses on malignant melanoma, discussing the current state of scientific knowledge and providing insights into the underlying basic mechanisms, the molecular changes, genetics and genomics.Human Melanoma is a dangerous type of skin cancer affecting an increasing population, and a better understanding of its development will help in finding sophisticated targeted therapies.The second revised edition features the latest research findings and offers updates on the latest advances and potential novel melanoma therapies. It is a valuable resource for researchers and clinicians working in the fields of melanoma, cancer research and therapy as well as dermatology.

Spis treści

Clinicopathologic Overview of Melanoma.- Revisiting Epidermal Melanocytes: Regulation of Their Survival, Proliferation, and Function in Human Skin.- Melanoma Epidemiology.- Melanoma Genetics and Genomics.- Transcriptional Regulation in Melanoma.- MiRNAs in Malignant Melanoma.- Altered Signal Transduction Pathways in Melanoma.- Proteases in Melanoma.- Cell-cell contacts in melanoma and the tumor microenvironment.- Regulation of Apoptosis in Melanoma Cells: Critical Targets for Therapeutic Strategies.- Senescence.-  Melanoma Stem Cells.- The Birth of Malignancy: Embryogenesis and Melanoma.- Tumor Microenvironment for Melanoma Cells.- Melanoma Model Systems.- New Approaches to Signaling.- Immune checkpoint inhibitors in melanoma define a new area in immunotherapy aiming for cure.

 

O autorze

Prof. Dr. Anja-Katrin Bosserhoff

Institute for Biochemistry

Friedrich-Alexander University Erlangen-Nürnberg

Germany