Medical Information Systems: The Laboratory Module

ISBN-13: 9781475714241 / Angielski / Miękka / 2012 / 430 str.

Ralph R. Grams; Ralph R. Grams

Opis

A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

Spis treści

Table of Contents Dopamine and Glutamate in Psychiatric Disorders Edited by Werner J. Schmidt and Maarten E. A. Reith Part I. Dopamine 1 Dopamine Receptor Alternative Splicing Neil M. Richtand, Laurel Pritchard, and Lique M. Coolen 2 Dopamine receptors Kim A. Neve Part II: Glutamate 3 Glutamatergic Pathways: Their relevance for psychiatric diseases Yoland Smith 4 Glutamate receptors: Ionotropic Daniel T. Monaghan, Julia C.A. More, Bihua Feng, and David Jane 5 Metabotropic Glutamate Receptors Krystyna Ossowska Part III: Schizophrenia 6 Dopamine and Schizophrenia Bart A. Ellenbroek 7 Glutamate and Schizophrenia and the N-methyl-D-aspartate receptor hypofunction hypothesis Stefan Bleich and Johannes Kornhuber 8 Role of glycine in schizophrenia Beate D. Kretschmer Part IV: Depression 9 Dopamine and Depression Phil Skolnick 10 Glutamate and Depression Joaquin Del Rio and Diana Frechilla Part V: Stress and aggression 11 Dopamine, Glutamate and Aggression Klaus A. Miczek and Eric W. Fish Part VI: Anxiety 12 Glutamatergic Systems and Anxiety David N. Stephens Part VII: Attention Deficit Hyperactivity Disorder 13 Dopamine and Glutamate in ADHD James M. Swanson, Nora D. Volkow, Jeffrey Newcorn, Betty J. Casey, Robert Moyzis, David K. Grandy, and Michael I. Posner Part VIII: Addiction 14 Dopamine-Glutamate Interactions in Reward-Related Incentive Learning Richard J.Beninger and Todor Gerdjikov 15 Sensitization and Relapse: Dopamine-Glutamate Interactions David A. Baker and Peter W. Kalivas 16 Glutamatergic neurotransmission in sensitization Thomas M. Tzschentke 17 Glutamatergic mechanisms of drug relapse: Withdrawal and conditioning factors Anton Y. Bespalov and Robert L. Balster Part IX: Neurodegeneration 18 Dopamine and neurodegeration Peter Riederer and Gabriele Gille 19 Glutamate and neurodegeneration Antonello Novelli, Marcos Perez-Basterrechea, and Maria Teresa Fernández-Sánchez Part X: Parkinson's Disease 20 Presymptomatic and symptomatic stages of intracerebral inclusion body pathology in idiopathic parkinson´s disease Heiko Braak and Kelly Del Tredici 21 Dopamine and Glutamate in Parkinson's Disease: Biochemistry, Clinic and Treatment Heinz Reichmann, Bernd Janetzky, and Peter Riederer 22 Dopamine and glutamate in motor and cognitive symptoms of Parkinson's disease Werner J. Schmidt Part XI: Huntington's disease 23 Dopamine and Glutamate in Huntington's disease Michael S. Levine, Carlos Cepeda, and Marjorie Ariano Part XII: Dementias 24 Dopaminergic and Glutamatergic Systems in Alzheimer's disease Paul T. Francis

Blurb

Now well recognized, the critical role of the inflammatory response in the pathophysiology of peripheral and central neurological disorders, including Alzheimer's and Parkinson's diseases, is today the subject of intense investigation at the molecular level. In Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, a panel of influential basic scientists review in detail the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidosis, HIV-associated dementia, and HTLV-associated neurological disorders.
Cutting-edge and authoritative, Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management offers basic research and clinical scientists an illuminating introduction to the new world of inflammatory CNS conditions and the emerging diagnostic and therapeutic opportunities they provide.