Mediators in Airway Hyperreactivity

ISBN-13: 9783034873819 / Angielski / Miękka / 2012 / 296 str.

Nijkamp;Engels;Henricks

Spis treści

Airway Hyperreactivity.- Airway hyperreactivity, an introduction.- An alternative point of view on experimental lung hyperreactivity.- Isolated and dual type of late asthmatic response (LAR) — The clinical characteristics and pharmacologic control.- Delayed asthmatic response (DAR) and its pharmacologic modulation.- Cytologic changes in the nasal secretions (NS) during the immediate (INR) and late nasal response (LNR) to allergen challenge (NPT).- Airway diameter determines flow-resistance and sensitivity to contractile mediators in perfused bronchial segments..- Modulating effects of antiasthmatic and antitussive drugs on autonomic neurotransmission in guinea-pig bronchial muscle in vitro.- Effect of subacute exposure to nitrogen dioxide on the airway responsiveness of guinea pig.- Tocoxara canis-induced airway hyporeactivity in mice.- Plasticisers, another burden for asthmatics ?.- Inflammatory Cells and Mediators.- Eicosanoids and inflammatory cells in asthma.- The effect of prostanoids on the function of human eosinophils.- Modulation of guinea pig airway reactivity by the linoleic acid metabolite, 13-hydroxy-octadecadienoic acid (13-HODE).- The effects of drugs on lung hyperreactivity in sephadex treated rats.- Adenyl cyclase activity in human alveolar macrophages.- Activated human granulocytes contract isolated human airways.- Pulmonary surfactant secretion in type II pneumocytes in inflamed condition.- Superoxide production by broncho-alveolar cells is diminished in parainfluenza-3 virus treated guinea pigs.- Oxidative stress and receptor responses in guinea-pig tracheal tissue.- Cytokines.- Cytokines and bronchial hyperreactivity.- Effect of lymphokines on ?-adrenoceptor stimulation of human PBMC.- A role for T cells in the induction of airway hyperreactivity.- Peptides.- Neuropeptides as modulators of airway function.- Modulation of cholinergic neurotransmission by VIP, VIP-antiserum and VIP-antagonists in dog and cat trachea: VIP plays a role of “double braking” in broncho-constriction.- Characterisation of the neurokinin receptors mediating contraction of isolated tracheal preparations from a variety of species.- Inhibition by calcitonin gene-related peptide of agonist-induced bronchoconstriction in various mammals including man.- Sensory neuropeptides are involved in cigarette smoke-induced airway hyperreactivity in guinea-pig.- Amino acids as modulators of cholinergic nerves in airways.- Contractile effects and receptor distributions for endothelin-1 (ET-1) in human and animal airways.- Binding characteristics of [125I] endothelin-1 in guineapig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21).- Endothelin-1 increases airway mucosa blood flow in the pig.- Platelet-Activating Factor.- PAF receptors in guinea-pig and human lung.- Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models.- Effects of a novel PAF antagonist, E6123, on PAF-induced biological responses.- Effects of a novel PAF antagonist, E6123, on passive anaphylaxis.- Epithelium-Derived Factors.- Putative role of epithelial derived factors in airway smooth muscle reactivity.- The role of epithelium in the responsiveness of the bronchi to stimuli.- Additive effect of epithelial denudation and low levels of inflammatory mediators on the sensitivity of isolated human airways to methacholine.- Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function.- Author index.