Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities

ISBN-13: 9781627039277 / Angielski / Miękka / 2014 / 762 str.

Joyce Tombran-Tink; Colin J. Barnstable; M. Bruce Shields

Opis

The mechanisms of the various forms of glaucoma were unknown at the outset of the twentieth century. Late in the twentieth century, two nascent areas of research were beginning to provide glimpses of what the twenty-first century held in store for the future of glaucoma: the mechanisms of glaucomatous optic neuropathy and the molecular basis of the glaucomas. In Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities, the authors review the most current knowledge available in the field and provide a basis in which researchers can effectively study the glaucomas. The intent of the book is not primarily to describe the clinical appearances of the glaucomas nor how to manage them. Rather, it is to provide basic scientists, who are working in the field of glaucoma, with a current understanding of the clinical aspects of glaucoma, and to provide clinician scientists with the basic knowledge, as they attempt to translate it into rational treatments for glaucoma. In this important new book leaders in the various fields of glaucoma review our current understanding of glaucoma from epidemiology and genetics through molecular, cellular and tissue responses to the mechanisms of the glaucomas and the mechanisms by which we manage them. Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities will be of great value as its contents will aid the reader in prevention of blindness from glaucoma.

Spis treści

Epidemiology of Glaucoma Introduction 1. Age and Racial Variation in the Prevalence of Open-Angle Glaucoma in the United States Joshua D. Stein, MD, MS, and Paul P. Lee, MD, JD 2. Epidemiology of and Risk Factors for Primary Open Angle Glaucoma Paulus T.V.M. de Jong, MD, PhD1,2,3 Nomdo M. Jansonius, MD, PhD3,4 Roger C.W.Wolfs, MD, PhD3,5 Richard H.C. Zegers, MD.2,3 3. The Reykjavik Eye Study on the Prevalence of Glaucoma in Iceland and Identified Risk Factors Fridbert Jonasson MD, Arsaell Arnarsson MSc, Thor Eysteinsson Ph D. 4. Defined Glaucoma in Chinese Population Chun Zhang1, Ningli Wang2, Wei Wang1 5. The Wroclaw Epidemiological Study: Screening Possibilities of Glaucoma Detection Radoslaw Kaczmarek, MD; Maria H. Nizankowska, MD, PhD Mechanisms of Intraocular Pressure Elevation in the Glaucomas Introduction 6. Pre Trabecular Mechanisms of Intraocular Pressure Elevation Sarwat Salim, MD and M. Bruce Shields, MD 7. Trabecular Mechanisms of Intraocular Pressure Elevation Douglas H Johnson, MD1 and Elke Lutjen-Drecoll, MD2 8. Trabecular Mechanisms: Pseudoexfoliation Syndrome Ursula Schlötzer-Schrehardt, PhD and Gottfried O.H. Naumann, MD 9. Posttrabecular Mechanisms with Elevated Episcleral Venous Pressure Augusto Paranhos, Jr, João Antonio Prata. Jr, Paulo Augusto de Arrude Mello, and Felicio Aristóteles da Silva 10. Angle Closure Glaucomas: Anterior (Pulling) Mechanisms Malik Y. Kahook, MD1 & Joel S. Schuman, MD2 11. Angle Closure Glaucomas: Posterior (Pushing) Mechanisms With Pupillary Block HiromuMishima 12. Angle Closure Glaucomas: Posterior (Pushing) Mechanisms without Pupillary Block Yaniv Barkana, MD Clement C. Tham, MD, Syril K. Dorairaj, MD, Robert Ritch, MD Genetics of Glaucoma Introduction 13. Genetics and Glaucoma Susceptibility Karim F. Damji1 and R. Rand Allingham2 14. Myocilin Mutations and their Role in Open Angle Glaucoma Dr Paul N. Baird, BSc Hons, PhD 15. The Functional Role of Myocilin in Glaucoma Ernst R. Tamm, MD 16. Role of Cyp1b1, Optineurin and WDR36 Gene Mutations in Glaucoma Mansoor Sarfarazi, Ph.D.1, Sharareh Monemi, M.D., Ph.D.1, Dharamainder Choudhary, Ph.D.1-2, Tayebeh Rezaie, Ph.D.1 and John Schenkman, Ph.D.2 17. Genetic Association in Primary Open Angle Glaucoma Fuu-Jen Tsai, MD, PhD,1 Hui-Ju Lin, MD 18. Apo E Polymorphisms and Severity of Open Angle Glaucoma Chi Pui Pang, Clement Chee Yung Tham, Dennis Shun Chiu Lam Molecular and Cellular responses in the eye to Glaucoma 19. Changes in Aqueous humor dynamics with Age and Glaucoma James C. H. Tan, B’Ann T. Gabelt, and Paul L. Kaufman 20. Mechanosensitive Genes in the Trabecular Meshwork at Homeostasis: Elevated Intraocular Pressure and Stretch Teresa Borrás, Ph.D. 21. Reactive Astrocytes in the Glaucomatous Optic Nerve Head: Protective and Destructive Mechanisms M. Rosario Hernandez, DDS and Bin Liu 22. Optic Neuropathy and Ganglion Cell Degeneration in Glaucoma: Mechanisms and Therapeutic Strategies. Dong Feng Chen, M.D., Ph.D. and Kin-Sang Cho, Ph.D. 23. Proteomics in Defining Pathogenic

Blurb

(Pending)

The mechanisms of the various forms of glaucoma were unknown at the outset of the twentieth century. Late in the twentieth century, two nascent areas of research were beginning to provide glimpses of what the twenty-first century held in store for the future of glaucoma: the mechanisms of glaucomatous optic neuropathy and the molecular basis of the glaucomas. In Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities, the authors review the most current knowledge available in the field and provide a basis in which researchers can effectively study the glaucomas. The intent of the book is not primarily to describe the clinical appearances of the glaucomas nor how to manage them. Rather, it is to provide basic scientists, who are working in the field of glaucoma, with a current understanding of the clinical aspects of glaucoma, and to provide clinician scientists with the basic knowledge, as they attempt to translate it into rational treatments for glaucoma. In this important new book leaders in the various fields of glaucoma review our current understanding of glaucoma from epidemiology and genetics through molecular, cellular and tissue responses to the mechanisms of the glaucomas and the mechanisms by which we manage them. Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities will be of great value as its contents will aid the reader in prevention of blindness from glaucoma.